node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DENND3 | NCLN | ENSP00000428714 | ENSP00000246117 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family. | 0.704 |
DENND3 | TBATA | ENSP00000428714 | ENSP00000400224 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. | 0.673 |
FOXN1 | PRSS16 | ENSP00000226247 | ENSP00000230582 | Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, includin [...] | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family. | 0.565 |
FOXN1 | PSMB11 | ENSP00000226247 | ENSP00000386212 | Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, includin [...] | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). Belongs to the peptidase T1B family. | 0.675 |
FOXN1 | TBATA | ENSP00000226247 | ENSP00000400224 | Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, includin [...] | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. | 0.435 |
NCLN | DENND3 | ENSP00000246117 | ENSP00000428714 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family. | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | 0.704 |
NCLN | NUP98 | ENSP00000246117 | ENSP00000316032 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family. | Nuclear pore complex protein Nup98-Nup96; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body). | 0.442 |
NCLN | TBATA | ENSP00000246117 | ENSP00000400224 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family. | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. | 0.743 |
NUP98 | NCLN | ENSP00000316032 | ENSP00000246117 | Nuclear pore complex protein Nup98-Nup96; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body). | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family. | 0.442 |
NUP98 | TBATA | ENSP00000316032 | ENSP00000400224 | Nuclear pore complex protein Nup98-Nup96; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body). | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. | 0.458 |
PAXBP1 | TBATA | ENSP00000328992 | ENSP00000400224 | PAX3- and PAX7-binding protein 1; Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity); Belongs to the GCF family. | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. | 0.485 |
PRSS16 | FOXN1 | ENSP00000230582 | ENSP00000226247 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family. | Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, includin [...] | 0.565 |
PRSS16 | PSMB11 | ENSP00000230582 | ENSP00000386212 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family. | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). Belongs to the peptidase T1B family. | 0.818 |
PRSS16 | TBATA | ENSP00000230582 | ENSP00000400224 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family. | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. | 0.614 |
PSMB11 | FOXN1 | ENSP00000386212 | ENSP00000226247 | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). Belongs to the peptidase T1B family. | Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, includin [...] | 0.675 |
PSMB11 | PRSS16 | ENSP00000386212 | ENSP00000230582 | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). Belongs to the peptidase T1B family. | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family. | 0.818 |
PSMB11 | TBATA | ENSP00000386212 | ENSP00000400224 | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). Belongs to the peptidase T1B family. | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. | 0.440 |
SLC46A2 | TBATA | ENSP00000363345 | ENSP00000400224 | Thymic stromal cotransporter homolog; May act as a transporter; Belongs to the major facilitator superfamily. SLC46A family. | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. | 0.465 |
SMIM19 | TBATA | ENSP00000391549 | ENSP00000400224 | Small integral membrane protein 19. | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. | 0.435 |
SUN5 | TBATA | ENSP00000348496 | ENSP00000400224 | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. | 0.447 |