node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6orf118 | TCP10 | ENSP00000230301 | ENSP00000484621 | Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118. | T-complex protein 10A homolog. | 0.447 |
C6orf118 | TCP10L2 | ENSP00000230301 | ENSP00000355797 | Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118. | T-complex protein 10A homolog 2; T-complex 10 like 2, pseudogene; Belongs to the TCP10 family. | 0.542 |
C6orf118 | UNC93A | ENSP00000230301 | ENSP00000230256 | Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118. | Unc-93 homolog A. | 0.418 |
GPR31 | TCP10 | ENSP00000355799 | ENSP00000484621 | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. | T-complex protein 10A homolog. | 0.431 |
GPR31 | TCP10L2 | ENSP00000355799 | ENSP00000355797 | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. | T-complex protein 10A homolog 2; T-complex 10 like 2, pseudogene; Belongs to the TCP10 family. | 0.527 |
GRIPAP1 | TCP10L2 | ENSP00000365606 | ENSP00000355797 | GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). | T-complex protein 10A homolog 2; T-complex 10 like 2, pseudogene; Belongs to the TCP10 family. | 0.684 |
NUTM2F | OR2T34 | ENSP00000253262 | ENSP00000330904 | NUT family member 2F; Belongs to the NUT family. | Olfactory receptor 2T34; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.507 |
NUTM2F | TCP10L2 | ENSP00000253262 | ENSP00000355797 | NUT family member 2F; Belongs to the NUT family. | T-complex protein 10A homolog 2; T-complex 10 like 2, pseudogene; Belongs to the TCP10 family. | 0.532 |
OR2T34 | NUTM2F | ENSP00000330904 | ENSP00000253262 | Olfactory receptor 2T34; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | NUT family member 2F; Belongs to the NUT family. | 0.507 |
OR2T34 | TCP10L2 | ENSP00000330904 | ENSP00000355797 | Olfactory receptor 2T34; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | T-complex protein 10A homolog 2; T-complex 10 like 2, pseudogene; Belongs to the TCP10 family. | 0.509 |
OR3A1 | TCP10 | ENSP00000313803 | ENSP00000484621 | Olfactory receptor 3A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | T-complex protein 10A homolog. | 0.597 |
OR3A1 | TCP10L2 | ENSP00000313803 | ENSP00000355797 | Olfactory receptor 3A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | T-complex protein 10A homolog 2; T-complex 10 like 2, pseudogene; Belongs to the TCP10 family. | 0.612 |
SASS6 | STIL | ENSP00000287482 | ENSP00000360944 | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification. | SCL-interrupting locus protein; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long- term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is es [...] | 0.996 |
SASS6 | TCP10 | ENSP00000287482 | ENSP00000484621 | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification. | T-complex protein 10A homolog. | 0.620 |
SASS6 | TCP10L2 | ENSP00000287482 | ENSP00000355797 | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification. | T-complex protein 10A homolog 2; T-complex 10 like 2, pseudogene; Belongs to the TCP10 family. | 0.478 |
STIL | SASS6 | ENSP00000360944 | ENSP00000287482 | SCL-interrupting locus protein; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long- term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is es [...] | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification. | 0.996 |
STIL | TCP10 | ENSP00000360944 | ENSP00000484621 | SCL-interrupting locus protein; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long- term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is es [...] | T-complex protein 10A homolog. | 0.671 |
STIL | TCP10L2 | ENSP00000360944 | ENSP00000355797 | SCL-interrupting locus protein; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long- term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is es [...] | T-complex protein 10A homolog 2; T-complex 10 like 2, pseudogene; Belongs to the TCP10 family. | 0.631 |
TCP10 | C6orf118 | ENSP00000484621 | ENSP00000230301 | T-complex protein 10A homolog. | Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118. | 0.447 |
TCP10 | GPR31 | ENSP00000484621 | ENSP00000355799 | T-complex protein 10A homolog. | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. | 0.431 |