node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRIX1 | BYSL | ENSP00000338862 | ENSP00000230340 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family. | 0.947 |
BRIX1 | LOC102724159 | ENSP00000338862 | ENSP00000482107 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Uncharacterized protein. | 0.655 |
BRIX1 | LTV1 | ENSP00000338862 | ENSP00000356548 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | 0.908 |
BRIX1 | PWP2 | ENSP00000338862 | ENSP00000291576 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Periodic tryptophan protein 2 homolog; PWP2 small subunit processome component. | 0.665 |
BRIX1 | RIOK2 | ENSP00000338862 | ENSP00000283109 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function. | 0.802 |
BRIX1 | TFB2M | ENSP00000338862 | ENSP00000355471 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Dimethyladenosine transferase 2, mitochondrial; S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- templ [...] | 0.898 |
BRIX1 | TSR1 | ENSP00000338862 | ENSP00000301364 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily. | 0.881 |
BYSL | BRIX1 | ENSP00000230340 | ENSP00000338862 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 0.947 |
BYSL | LOC102724159 | ENSP00000230340 | ENSP00000482107 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family. | Uncharacterized protein. | 0.978 |
BYSL | LTV1 | ENSP00000230340 | ENSP00000356548 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family. | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | 0.999 |
BYSL | POLRMT | ENSP00000230340 | ENSP00000465759 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family. | DNA-directed RNA polymerase, mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. | 0.433 |
BYSL | PWP2 | ENSP00000230340 | ENSP00000291576 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family. | Periodic tryptophan protein 2 homolog; PWP2 small subunit processome component. | 0.998 |
BYSL | RIOK2 | ENSP00000230340 | ENSP00000283109 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family. | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function. | 0.999 |
BYSL | TFB2M | ENSP00000230340 | ENSP00000355471 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family. | Dimethyladenosine transferase 2, mitochondrial; S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- templ [...] | 0.981 |
BYSL | TSR1 | ENSP00000230340 | ENSP00000301364 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family. | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily. | 0.999 |
LOC102724159 | BRIX1 | ENSP00000482107 | ENSP00000338862 | Uncharacterized protein. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 0.655 |
LOC102724159 | BYSL | ENSP00000482107 | ENSP00000230340 | Uncharacterized protein. | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family. | 0.978 |
LOC102724159 | LTV1 | ENSP00000482107 | ENSP00000356548 | Uncharacterized protein. | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | 0.479 |
LOC102724159 | POLRMT | ENSP00000482107 | ENSP00000465759 | Uncharacterized protein. | DNA-directed RNA polymerase, mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. | 0.541 |
LOC102724159 | PWP2 | ENSP00000482107 | ENSP00000291576 | Uncharacterized protein. | Periodic tryptophan protein 2 homolog; PWP2 small subunit processome component. | 0.542 |