node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DBT | GTPBP10 | ENSP00000359151 | ENSP00000222511 | 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. | GTP-binding protein 10; May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.447 |
DBT | THAP6 | ENSP00000359151 | ENSP00000309007 | 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. | THAP domain containing 6. | 0.507 |
FBXO47 | THAP6 | ENSP00000367319 | ENSP00000309007 | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. | THAP domain containing 6. | 0.495 |
GTPBP10 | DBT | ENSP00000222511 | ENSP00000359151 | GTP-binding protein 10; May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. | 0.447 |
GTPBP10 | THAP6 | ENSP00000222511 | ENSP00000309007 | GTP-binding protein 10; May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | THAP domain containing 6. | 0.507 |
PKIA | THAP6 | ENSP00000379696 | ENSP00000309007 | cAMP-dependent protein kinase inhibitor alpha; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. | THAP domain containing 6. | 0.540 |
THAP10 | THAP3 | ENSP00000249861 | ENSP00000054650 | THAP domain containing 10. | THAP domain-containing protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. | 0.570 |
THAP10 | THAP5 | ENSP00000249861 | ENSP00000400500 | THAP domain containing 10. | THAP domain-containing protein 5; Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase. | 0.583 |
THAP10 | THAP6 | ENSP00000249861 | ENSP00000309007 | THAP domain containing 10. | THAP domain containing 6. | 0.611 |
THAP10 | THAP8 | ENSP00000249861 | ENSP00000292894 | THAP domain containing 10. | THAP domain containing 8. | 0.701 |
THAP3 | THAP10 | ENSP00000054650 | ENSP00000249861 | THAP domain-containing protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. | THAP domain containing 10. | 0.570 |
THAP3 | THAP6 | ENSP00000054650 | ENSP00000309007 | THAP domain-containing protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. | THAP domain containing 6. | 0.624 |
THAP3 | THAP8 | ENSP00000054650 | ENSP00000292894 | THAP domain-containing protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. | THAP domain containing 8. | 0.503 |
THAP5 | THAP10 | ENSP00000400500 | ENSP00000249861 | THAP domain-containing protein 5; Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase. | THAP domain containing 10. | 0.583 |
THAP5 | THAP6 | ENSP00000400500 | ENSP00000309007 | THAP domain-containing protein 5; Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase. | THAP domain containing 6. | 0.500 |
THAP6 | DBT | ENSP00000309007 | ENSP00000359151 | THAP domain containing 6. | 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. | 0.507 |
THAP6 | FBXO47 | ENSP00000309007 | ENSP00000367319 | THAP domain containing 6. | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. | 0.495 |
THAP6 | GTPBP10 | ENSP00000309007 | ENSP00000222511 | THAP domain containing 6. | GTP-binding protein 10; May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.507 |
THAP6 | PKIA | ENSP00000309007 | ENSP00000379696 | THAP domain containing 6. | cAMP-dependent protein kinase inhibitor alpha; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. | 0.540 |
THAP6 | THAP10 | ENSP00000309007 | ENSP00000249861 | THAP domain containing 6. | THAP domain containing 10. | 0.611 |