node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B3GLCT | THSD4 | ENSP00000343002 | ENSP00000347484 | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). | 0.510 |
FAM13A | GSTCD | ENSP00000264344 | ENSP00000422354 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | 0.708 |
FAM13A | HHIP | ENSP00000264344 | ENSP00000296575 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | 0.854 |
FAM13A | INTS12 | ENSP00000264344 | ENSP00000415433 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.574 |
FAM13A | LRMDA | ENSP00000264344 | ENSP00000480240 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation. | 0.431 |
FAM13A | PID1 | ENSP00000264344 | ENSP00000283937 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | PTB-containing, cubilin and LRP1-interacting protein; Increases proliferation of preadipocytes without affecting adipocytic differentiation. | 0.584 |
FAM13A | THSD4 | ENSP00000264344 | ENSP00000347484 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). | 0.601 |
FAM13A | TNS1 | ENSP00000264344 | ENSP00000171887 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Tensin-1; Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. | 0.447 |
GSTCD | FAM13A | ENSP00000422354 | ENSP00000264344 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | 0.708 |
GSTCD | HHIP | ENSP00000422354 | ENSP00000296575 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | 0.632 |
GSTCD | INTS12 | ENSP00000422354 | ENSP00000415433 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.775 |
GSTCD | LRMDA | ENSP00000422354 | ENSP00000480240 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation. | 0.523 |
GSTCD | PID1 | ENSP00000422354 | ENSP00000283937 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | PTB-containing, cubilin and LRP1-interacting protein; Increases proliferation of preadipocytes without affecting adipocytic differentiation. | 0.576 |
GSTCD | THSD4 | ENSP00000422354 | ENSP00000347484 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). | 0.702 |
GSTCD | TNS1 | ENSP00000422354 | ENSP00000171887 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | Tensin-1; Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. | 0.587 |
HHIP | FAM13A | ENSP00000296575 | ENSP00000264344 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | 0.854 |
HHIP | GSTCD | ENSP00000296575 | ENSP00000422354 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | 0.632 |
HHIP | PID1 | ENSP00000296575 | ENSP00000283937 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | PTB-containing, cubilin and LRP1-interacting protein; Increases proliferation of preadipocytes without affecting adipocytic differentiation. | 0.447 |
HHIP | THSD4 | ENSP00000296575 | ENSP00000347484 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). | 0.519 |
INTS12 | FAM13A | ENSP00000415433 | ENSP00000264344 | Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | 0.574 |