node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKR1B1 | TM6SF1 | ENSP00000285930 | ENSP00000317000 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | 0.448 |
ARHGEF7 | TM6SF1 | ENSP00000495631 | ENSP00000317000 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | 0.445 |
EBPL | TM6SF1 | ENSP00000242827 | ENSP00000317000 | Emopamil-binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands. | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | 0.438 |
HAPLN4 | TM6SF1 | ENSP00000291481 | ENSP00000317000 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | 0.948 |
RASGRF2 | TM6SF1 | ENSP00000265080 | ENSP00000317000 | Ras-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | 0.574 |
RASGRF2 | TMEFF2 | ENSP00000265080 | ENSP00000272771 | Ras-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. | Tomoregulin-2; May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. Belongs to the tomoregulin family. | 0.428 |
TLX3 | TM6SF1 | ENSP00000296921 | ENSP00000317000 | T cell leukemia homeobox 3. | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | 0.449 |
TLX3 | TRIM58 | ENSP00000296921 | ENSP00000355437 | T cell leukemia homeobox 3. | E3 ubiquitin-protein ligase TRIM58; E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. | 0.414 |
TM6SF1 | AKR1B1 | ENSP00000317000 | ENSP00000285930 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | 0.448 |
TM6SF1 | ARHGEF7 | ENSP00000317000 | ENSP00000495631 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. | 0.445 |
TM6SF1 | EBPL | ENSP00000317000 | ENSP00000242827 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Emopamil-binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands. | 0.438 |
TM6SF1 | HAPLN4 | ENSP00000317000 | ENSP00000291481 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | 0.948 |
TM6SF1 | RASGRF2 | ENSP00000317000 | ENSP00000265080 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Ras-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. | 0.574 |
TM6SF1 | TLX3 | ENSP00000317000 | ENSP00000296921 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | T cell leukemia homeobox 3. | 0.449 |
TM6SF1 | TMEFF2 | ENSP00000317000 | ENSP00000272771 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Tomoregulin-2; May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. Belongs to the tomoregulin family. | 0.571 |
TM6SF1 | TMEM182 | ENSP00000317000 | ENSP00000394178 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Transmembrane protein 182. | 0.499 |
TM6SF1 | TRIM58 | ENSP00000317000 | ENSP00000355437 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | E3 ubiquitin-protein ligase TRIM58; E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. | 0.561 |
TM6SF1 | TSPAN33 | ENSP00000317000 | ENSP00000483872 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7. | 0.447 |
TMEFF2 | RASGRF2 | ENSP00000272771 | ENSP00000265080 | Tomoregulin-2; May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. Belongs to the tomoregulin family. | Ras-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. | 0.428 |
TMEFF2 | TM6SF1 | ENSP00000272771 | ENSP00000317000 | Tomoregulin-2; May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. Belongs to the tomoregulin family. | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | 0.571 |