STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM120ATransmembrane protein 120A; Necessary for efficient adipogenesis. Belongs to the TMEM120 family. (369 aa)    
Predicted Functional Partners:
B4GALT3
Beta-1,4-galactosyltransferase 3; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
   
   0.649
PLPP7
Inactive phospholipid phosphatase 7; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).
   
  
 0.644
TMEM120B
Transmembrane protein 120B; Necessary for efficient adipogenesis. Belongs to the TMEM120 family.
  
 
 
0.633
TMEM150C
Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family.
      
 0.541
TPRG1
Tumor protein p63 regulated 1; Belongs to the TPRG1 family.
    
   0.535
STYXL1
Serine/threonine/tyrosine-interacting-like protein 1; Catalytically inactive phosphatase. By binding to G3BP1, inhibits the formation of G3BP1- induced stress granules. Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149'. Inhibits PTPMT1 phosphatase activity. By inhibiting PTPMT1, positively regulates intrinsic apoptosis. May play a role in the formation of neurites during neuronal development. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.
 
 
  
 0.523
TMEM101
Transmembrane protein 101; May activate NF-kappa-B signaling pathways.
   
  
 0.518
TMEM60
Transmembrane protein 60.
   
  
 0.513
TM7SF2
Delta(14)-sterol reductase TM7SF2; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
   
  
 0.511
TMEM38A
Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
   
  
 0.498
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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