node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DRD5 | OTOP1 | ENSP00000306129 | ENSP00000296358 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Proton channel OTOP1; Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly- sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for [...] | 0.467 |
DRD5 | TMEM128 | ENSP00000306129 | ENSP00000372201 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Transmembrane protein 128. | 0.475 |
FAM47C | TMEM128 | ENSP00000367913 | ENSP00000372201 | Putative protein FAM47C; Family with sequence similarity 47 member C; Belongs to the FAM47 family. | Transmembrane protein 128. | 0.506 |
OR2A7 | TMEM128 | ENSP00000493320 | ENSP00000372201 | Olfactory receptor 2A7; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Transmembrane protein 128. | 0.479 |
OTOP1 | DRD5 | ENSP00000296358 | ENSP00000306129 | Proton channel OTOP1; Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly- sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for [...] | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.467 |
OTOP1 | TMEM128 | ENSP00000296358 | ENSP00000372201 | Proton channel OTOP1; Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly- sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for [...] | Transmembrane protein 128. | 0.679 |
OTOP2 | TMEM128 | ENSP00000332528 | ENSP00000372201 | Proton channel OTOP2; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Belongs to the otopetrin family. | Transmembrane protein 128. | 0.452 |
PLSCR1 | TMEM128 | ENSP00000345494 | ENSP00000372201 | Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. | Transmembrane protein 128. | 0.474 |
RABAC1 | TMEM128 | ENSP00000222008 | ENSP00000372201 | Prenylated Rab acceptor protein 1; General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI. Belongs to the PRA1 family. | Transmembrane protein 128. | 0.519 |
TMEM128 | DRD5 | ENSP00000372201 | ENSP00000306129 | Transmembrane protein 128. | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.475 |
TMEM128 | FAM47C | ENSP00000372201 | ENSP00000367913 | Transmembrane protein 128. | Putative protein FAM47C; Family with sequence similarity 47 member C; Belongs to the FAM47 family. | 0.506 |
TMEM128 | OR2A7 | ENSP00000372201 | ENSP00000493320 | Transmembrane protein 128. | Olfactory receptor 2A7; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.479 |
TMEM128 | OTOP1 | ENSP00000372201 | ENSP00000296358 | Transmembrane protein 128. | Proton channel OTOP1; Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly- sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for [...] | 0.679 |
TMEM128 | OTOP2 | ENSP00000372201 | ENSP00000332528 | Transmembrane protein 128. | Proton channel OTOP2; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Belongs to the otopetrin family. | 0.452 |
TMEM128 | PLSCR1 | ENSP00000372201 | ENSP00000345494 | Transmembrane protein 128. | Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. | 0.474 |
TMEM128 | RABAC1 | ENSP00000372201 | ENSP00000222008 | Transmembrane protein 128. | Prenylated Rab acceptor protein 1; General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI. Belongs to the PRA1 family. | 0.519 |
TMEM128 | TMEM179 | ENSP00000372201 | ENSP00000450958 | Transmembrane protein 128. | Transmembrane protein 179; Belongs to the TMEM179 family. | 0.479 |
TMEM128 | WDR1 | ENSP00000372201 | ENSP00000427687 | Transmembrane protein 128. | WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin- mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape cha [...] | 0.439 |
TMEM128 | ZBTB49 | ENSP00000372201 | ENSP00000338807 | Transmembrane protein 128. | Zinc finger and BTB domain-containing protein 49; Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. [Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.580 |
TMEM179 | TMEM128 | ENSP00000450958 | ENSP00000372201 | Transmembrane protein 179; Belongs to the TMEM179 family. | Transmembrane protein 128. | 0.479 |