STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM132ETransmembrane protein 132E; Required for normal inner ear hair cell function and hearing. Belongs to the TMEM132 family. (1074 aa)    
Predicted Functional Partners:
TMEM221
Transmembrane protein 221.
      
 0.589
CYLC1
Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.
      
 0.516
MFSD12
Major facilitator superfamily domain containing 12.
      
 0.498
WDR27
WD repeat domain 27.
      
 0.469
FRMPD3
FERM and PDZ domain containing 3.
   
  
 0.462
TMEM211
Transmembrane protein 211.
      
 0.462
GPR137C
Integral membrane protein GPR137C; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes; Belongs to the GPR137 family.
   
  
 0.460
ZC4H2
Zinc finger C4H2 domain-containing protein; Plays a role in interneurons differentiation. Involved in neuronal development and in neuromuscular junction formation.
      
 0.443
GPR162
Probable G-protein coupled receptor 162; Orphan receptor.
   
  
 0.442
OVOL3
Putative transcription factor ovo-like protein 3; May act as a transcription regulator; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.441
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.