node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARFIP1 | TMEM154 | ENSP00000296557 | ENSP00000302144 | Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. | Transmembrane protein 154. | 0.542 |
DPPA2 | TMEM154 | ENSP00000417710 | ENSP00000302144 | Developmental pluripotency-associated protein 2; Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. | Transmembrane protein 154. | 0.532 |
DPPA2 | TMEM38A | ENSP00000417710 | ENSP00000187762 | Developmental pluripotency-associated protein 2; Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. | Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. | 0.531 |
LACTBL1 | TMEM154 | ENSP00000402297 | ENSP00000302144 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | Transmembrane protein 154. | 0.480 |
PRR16 | TMEM154 | ENSP00000385118 | ENSP00000302144 | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration. | Transmembrane protein 154. | 0.487 |
SMIM7 | SYTL3 | ENSP00000486146 | ENSP00000483936 | Small integral membrane protein 7. | Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). | 0.418 |
SMIM7 | TMEM154 | ENSP00000486146 | ENSP00000302144 | Small integral membrane protein 7. | Transmembrane protein 154. | 0.478 |
SMIM7 | TMEM38A | ENSP00000486146 | ENSP00000187762 | Small integral membrane protein 7. | Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. | 0.668 |
SMIM7 | ZSCAN16 | ENSP00000486146 | ENSP00000366527 | Small integral membrane protein 7. | Zinc finger and SCAN domain-containing protein 16; May be involved in transcriptional regulation. | 0.407 |
SYTL3 | SMIM7 | ENSP00000483936 | ENSP00000486146 | Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). | Small integral membrane protein 7. | 0.418 |
SYTL3 | TMEM154 | ENSP00000483936 | ENSP00000302144 | Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). | Transmembrane protein 154. | 0.594 |
SYTL3 | TMEM38A | ENSP00000483936 | ENSP00000187762 | Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). | Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. | 0.502 |
SYTL3 | ZSCAN16 | ENSP00000483936 | ENSP00000366527 | Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). | Zinc finger and SCAN domain-containing protein 16; May be involved in transcriptional regulation. | 0.432 |
TMEM154 | ARFIP1 | ENSP00000302144 | ENSP00000296557 | Transmembrane protein 154. | Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. | 0.542 |
TMEM154 | DPPA2 | ENSP00000302144 | ENSP00000417710 | Transmembrane protein 154. | Developmental pluripotency-associated protein 2; Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. | 0.532 |
TMEM154 | LACTBL1 | ENSP00000302144 | ENSP00000402297 | Transmembrane protein 154. | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | 0.480 |
TMEM154 | PRR16 | ENSP00000302144 | ENSP00000385118 | Transmembrane protein 154. | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration. | 0.487 |
TMEM154 | SMIM7 | ENSP00000302144 | ENSP00000486146 | Transmembrane protein 154. | Small integral membrane protein 7. | 0.478 |
TMEM154 | SYTL3 | ENSP00000302144 | ENSP00000483936 | Transmembrane protein 154. | Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). | 0.594 |
TMEM154 | TMEM223 | ENSP00000302144 | ENSP00000303987 | Transmembrane protein 154. | Transmembrane protein 223. | 0.486 |