node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC6 | TMEM161A | ENSP00000444156 | ENSP00000162044 | Armadillo repeat containing 6. | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | 0.563 |
ASB14 | TMEM161A | ENSP00000419199 | ENSP00000162044 | Ankyrin repeat and SOCS box protein 14; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | 0.478 |
C11orf1 | TMEM161A | ENSP00000260276 | ENSP00000162044 | UPF0686 protein C11orf1; Chromosome 11 open reading frame 1. | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | 0.506 |
CASKIN2 | TMEM161A | ENSP00000325355 | ENSP00000162044 | Caskin-2; CASK interacting protein 2. | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | 0.494 |
CASKIN2 | TMEM94 | ENSP00000325355 | ENSP00000364397 | Caskin-2; CASK interacting protein 2. | Transmembrane protein 94. | 0.625 |
KLHL31 | POPDC2 | ENSP00000359942 | ENSP00000264231 | Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family. | 0.448 |
KLHL31 | TMEM161A | ENSP00000359942 | ENSP00000162044 | Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | 0.490 |
KLHL31 | TMEM38A | ENSP00000359942 | ENSP00000187762 | Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). | Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. | 0.589 |
POPDC2 | KLHL31 | ENSP00000264231 | ENSP00000359942 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family. | Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). | 0.448 |
POPDC2 | TMEM161A | ENSP00000264231 | ENSP00000162044 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family. | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | 0.520 |
POPDC2 | TMEM38A | ENSP00000264231 | ENSP00000187762 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family. | Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. | 0.497 |
RSAD1 | TMEM161A | ENSP00000258955 | ENSP00000162044 | Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity (Probable). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine (By similarity); Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily. | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | 0.475 |
SLC25A42 | TMEM161A | ENSP00000326693 | ENSP00000162044 | Mitochondrial coenzyme A transporter SLC25A42; Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate. | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | 0.610 |
SLC25A42 | TMEM94 | ENSP00000326693 | ENSP00000364397 | Mitochondrial coenzyme A transporter SLC25A42; Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate. | Transmembrane protein 94. | 0.456 |
TMEM161A | ARMC6 | ENSP00000162044 | ENSP00000444156 | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | Armadillo repeat containing 6. | 0.563 |
TMEM161A | ASB14 | ENSP00000162044 | ENSP00000419199 | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | Ankyrin repeat and SOCS box protein 14; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.478 |
TMEM161A | C11orf1 | ENSP00000162044 | ENSP00000260276 | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | UPF0686 protein C11orf1; Chromosome 11 open reading frame 1. | 0.506 |
TMEM161A | CASKIN2 | ENSP00000162044 | ENSP00000325355 | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | Caskin-2; CASK interacting protein 2. | 0.494 |
TMEM161A | KLHL31 | ENSP00000162044 | ENSP00000359942 | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). | 0.490 |
TMEM161A | POPDC2 | ENSP00000162044 | ENSP00000264231 | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family. | 0.520 |