node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LMOD3 | TMEM182 | ENSP00000414670 | ENSP00000394178 | Leiomodin-3; Essential for the organization of sarcomeric actin thin filaments in skeletal muscle. Increases the rate of actin polymerization ; Belongs to the tropomodulin family. | Transmembrane protein 182. | 0.433 |
MCTP2 | TMEM182 | ENSP00000350377 | ENSP00000394178 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | Transmembrane protein 182. | 0.472 |
MFSD9 | TMEM182 | ENSP00000258436 | ENSP00000394178 | Major facilitator superfamily domain containing 9. | Transmembrane protein 182. | 0.671 |
MYMK | TMEM182 | ENSP00000419712 | ENSP00000394178 | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX. Acts independently of MYMX (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satell [...] | Transmembrane protein 182. | 0.433 |
PLCH2 | TMEM182 | ENSP00000367747 | ENSP00000394178 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity). | Transmembrane protein 182. | 0.448 |
RIT1 | TMEM182 | ENSP00000357305 | ENSP00000394178 | GTP-binding protein Rit1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation; Belongs to the small GTPase superfamily. Ras family. | Transmembrane protein 182. | 0.593 |
SHISAL2B | TMEM182 | ENSP00000373726 | ENSP00000394178 | Protein shisa-like-2B; Shisa like 2B. | Transmembrane protein 182. | 0.440 |
TAFA1 | TMEM182 | ENSP00000418575 | ENSP00000394178 | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | Transmembrane protein 182. | 0.422 |
TM6SF1 | TMEM182 | ENSP00000317000 | ENSP00000394178 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Transmembrane protein 182. | 0.499 |
TMEM182 | LMOD3 | ENSP00000394178 | ENSP00000414670 | Transmembrane protein 182. | Leiomodin-3; Essential for the organization of sarcomeric actin thin filaments in skeletal muscle. Increases the rate of actin polymerization ; Belongs to the tropomodulin family. | 0.433 |
TMEM182 | MCTP2 | ENSP00000394178 | ENSP00000350377 | Transmembrane protein 182. | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | 0.472 |
TMEM182 | MFSD9 | ENSP00000394178 | ENSP00000258436 | Transmembrane protein 182. | Major facilitator superfamily domain containing 9. | 0.671 |
TMEM182 | MYMK | ENSP00000394178 | ENSP00000419712 | Transmembrane protein 182. | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX. Acts independently of MYMX (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satell [...] | 0.433 |
TMEM182 | PLCH2 | ENSP00000394178 | ENSP00000367747 | Transmembrane protein 182. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity). | 0.448 |
TMEM182 | RIT1 | ENSP00000394178 | ENSP00000357305 | Transmembrane protein 182. | GTP-binding protein Rit1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation; Belongs to the small GTPase superfamily. Ras family. | 0.593 |
TMEM182 | SHISAL2B | ENSP00000394178 | ENSP00000373726 | Transmembrane protein 182. | Protein shisa-like-2B; Shisa like 2B. | 0.440 |
TMEM182 | TAFA1 | ENSP00000394178 | ENSP00000418575 | Transmembrane protein 182. | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | 0.422 |
TMEM182 | TM6SF1 | ENSP00000394178 | ENSP00000317000 | Transmembrane protein 182. | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | 0.499 |
TMEM182 | VWC2L | ENSP00000394178 | ENSP00000308976 | Transmembrane protein 182. | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization. | 0.438 |
VWC2L | TMEM182 | ENSP00000308976 | ENSP00000394178 | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization. | Transmembrane protein 182. | 0.438 |