node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | TMEM200A | ENSP00000295897 | ENSP00000376224 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific man [...] | Transmembrane protein 200A; Belongs to the TMEM200 family. | 0.514 |
GOSR1 | STX10 | ENSP00000225724 | ENSP00000466298 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family. | 0.853 |
GOSR1 | TMEM200A | ENSP00000225724 | ENSP00000376224 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | Transmembrane protein 200A; Belongs to the TMEM200 family. | 0.535 |
PPP3CA | PPP3CB | ENSP00000378323 | ENSP00000378306 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylat [...] | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32 ; Belongs to the PPP phosphatase family. PP-2B subfamily. | 0.994 |
PPP3CA | TMEM200A | ENSP00000378323 | ENSP00000376224 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylat [...] | Transmembrane protein 200A; Belongs to the TMEM200 family. | 0.490 |
PPP3CB | PPP3CA | ENSP00000378306 | ENSP00000378323 | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32 ; Belongs to the PPP phosphatase family. PP-2B subfamily. | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylat [...] | 0.994 |
PPP3CB | TMEM200A | ENSP00000378306 | ENSP00000376224 | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32 ; Belongs to the PPP phosphatase family. PP-2B subfamily. | Transmembrane protein 200A; Belongs to the TMEM200 family. | 0.603 |
RPL27A | TMEM200A | ENSP00000346015 | ENSP00000376224 | Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family. | Transmembrane protein 200A; Belongs to the TMEM200 family. | 0.466 |
SEBOX | TMEM200A | ENSP00000444503 | ENSP00000376224 | Homeobox protein SEBOX; Probable transcription factor involved in the control of specification of mesoderm and endoderm; Belongs to the paired homeobox family. | Transmembrane protein 200A; Belongs to the TMEM200 family. | 0.475 |
STX10 | GOSR1 | ENSP00000466298 | ENSP00000225724 | Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.853 |
STX10 | TMEM200A | ENSP00000466298 | ENSP00000376224 | Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family. | Transmembrane protein 200A; Belongs to the TMEM200 family. | 0.461 |
TC2N | TMEM200A | ENSP00000387882 | ENSP00000376224 | Tandem C2 domains, nuclear. | Transmembrane protein 200A; Belongs to the TMEM200 family. | 0.450 |
THEM6 | TMEM200A | ENSP00000338607 | ENSP00000376224 | Protein THEM6; Thioesterase superfamily member 6. | Transmembrane protein 200A; Belongs to the TMEM200 family. | 0.458 |
TMEM200A | ALB | ENSP00000376224 | ENSP00000295897 | Transmembrane protein 200A; Belongs to the TMEM200 family. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific man [...] | 0.514 |
TMEM200A | GOSR1 | ENSP00000376224 | ENSP00000225724 | Transmembrane protein 200A; Belongs to the TMEM200 family. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.535 |
TMEM200A | PPP3CA | ENSP00000376224 | ENSP00000378323 | Transmembrane protein 200A; Belongs to the TMEM200 family. | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylat [...] | 0.490 |
TMEM200A | PPP3CB | ENSP00000376224 | ENSP00000378306 | Transmembrane protein 200A; Belongs to the TMEM200 family. | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32 ; Belongs to the PPP phosphatase family. PP-2B subfamily. | 0.603 |
TMEM200A | RPL27A | ENSP00000376224 | ENSP00000346015 | Transmembrane protein 200A; Belongs to the TMEM200 family. | Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family. | 0.466 |
TMEM200A | SEBOX | ENSP00000376224 | ENSP00000444503 | Transmembrane protein 200A; Belongs to the TMEM200 family. | Homeobox protein SEBOX; Probable transcription factor involved in the control of specification of mesoderm and endoderm; Belongs to the paired homeobox family. | 0.475 |
TMEM200A | STX10 | ENSP00000376224 | ENSP00000466298 | Transmembrane protein 200A; Belongs to the TMEM200 family. | Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family. | 0.461 |