node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY1 | TMEM200C | ENSP00000297323 | ENSP00000463375 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Transmembrane protein 200C. | 0.411 |
ALB | TMEM200C | ENSP00000295897 | ENSP00000463375 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific man [...] | Transmembrane protein 200C. | 0.532 |
ARTN | TMEM200C | ENSP00000387435 | ENSP00000463375 | Artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. | Transmembrane protein 200C. | 0.405 |
C18orf25 | RNF165 | ENSP00000481626 | ENSP00000269439 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Belongs to the Arkadia family. | 0.645 |
C18orf25 | TMEM200C | ENSP00000481626 | ENSP00000463375 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | Transmembrane protein 200C. | 0.479 |
GDF7 | TMEM200C | ENSP00000272224 | ENSP00000463375 | Growth/differentiation factor 7; May play an active role in the motor area of the primate neocortex. | Transmembrane protein 200C. | 0.509 |
L3MBTL4 | TMEM200C | ENSP00000382976 | ENSP00000463375 | Lethal(3)malignant brain tumor-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). | Transmembrane protein 200C. | 0.422 |
MTHFSD | SYCP2 | ENSP00000354152 | ENSP00000350162 | Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing. | Synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements; Belongs [...] | 0.440 |
MTHFSD | TMEM200C | ENSP00000354152 | ENSP00000463375 | Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing. | Transmembrane protein 200C. | 0.546 |
RNF165 | C18orf25 | ENSP00000269439 | ENSP00000481626 | E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Belongs to the Arkadia family. | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | 0.645 |
RNF165 | TMEM200C | ENSP00000269439 | ENSP00000463375 | E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Belongs to the Arkadia family. | Transmembrane protein 200C. | 0.439 |
SYCP2 | MTHFSD | ENSP00000350162 | ENSP00000354152 | Synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements; Belongs [...] | Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing. | 0.440 |
SYCP2 | TMEM200C | ENSP00000350162 | ENSP00000463375 | Synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements; Belongs [...] | Transmembrane protein 200C. | 0.461 |
SYCP2L | TMEM200C | ENSP00000283141 | ENSP00000463375 | Synaptonemal complex protein 2-like; Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes. Belongs to the SYCP2 family. | Transmembrane protein 200C. | 0.542 |
TMEM200C | ADCY1 | ENSP00000463375 | ENSP00000297323 | Transmembrane protein 200C. | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.411 |
TMEM200C | ALB | ENSP00000463375 | ENSP00000295897 | Transmembrane protein 200C. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific man [...] | 0.532 |
TMEM200C | ARTN | ENSP00000463375 | ENSP00000387435 | Transmembrane protein 200C. | Artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. | 0.405 |
TMEM200C | C18orf25 | ENSP00000463375 | ENSP00000481626 | Transmembrane protein 200C. | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | 0.479 |
TMEM200C | GDF7 | ENSP00000463375 | ENSP00000272224 | Transmembrane protein 200C. | Growth/differentiation factor 7; May play an active role in the motor area of the primate neocortex. | 0.509 |
TMEM200C | L3MBTL4 | ENSP00000463375 | ENSP00000382976 | Transmembrane protein 200C. | Lethal(3)malignant brain tumor-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). | 0.422 |