node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD13B | TMEM25 | ENSP00000378328 | ENSP00000431548 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.533 |
ANKRD13B | TMEM91 | ENSP00000378328 | ENSP00000375859 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Transmembrane protein 91; Belongs to the CD225/Dispanin family. | 0.534 |
HGD | TMEM25 | ENSP00000283871 | ENSP00000431548 | Homogentisate 1,2-dioxygenase. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.531 |
NDC1 | RTP3 | ENSP00000360483 | ENSP00000296142 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. | Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family. | 0.474 |
NDC1 | TMEM116 | ENSP00000360483 | ENSP00000447731 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. | Transmembrane protein 116. | 0.506 |
NDC1 | TMEM207 | ENSP00000360483 | ENSP00000346981 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. | Transmembrane protein 207. | 0.433 |
NDC1 | TMEM213 | ENSP00000360483 | ENSP00000390407 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. | Transmembrane protein 213. | 0.480 |
NDC1 | TMEM25 | ENSP00000360483 | ENSP00000431548 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.541 |
RTP3 | NDC1 | ENSP00000296142 | ENSP00000360483 | Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family. | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. | 0.474 |
RTP3 | TMEM116 | ENSP00000296142 | ENSP00000447731 | Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family. | Transmembrane protein 116. | 0.513 |
RTP3 | TMEM207 | ENSP00000296142 | ENSP00000346981 | Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family. | Transmembrane protein 207. | 0.479 |
RTP3 | TMEM213 | ENSP00000296142 | ENSP00000390407 | Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family. | Transmembrane protein 213. | 0.528 |
RTP3 | TMEM25 | ENSP00000296142 | ENSP00000431548 | Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.571 |
TMEM116 | NDC1 | ENSP00000447731 | ENSP00000360483 | Transmembrane protein 116. | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. | 0.506 |
TMEM116 | RTP3 | ENSP00000447731 | ENSP00000296142 | Transmembrane protein 116. | Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family. | 0.513 |
TMEM116 | TMEM207 | ENSP00000447731 | ENSP00000346981 | Transmembrane protein 116. | Transmembrane protein 207. | 0.575 |
TMEM116 | TMEM213 | ENSP00000447731 | ENSP00000390407 | Transmembrane protein 116. | Transmembrane protein 213. | 0.595 |
TMEM116 | TMEM25 | ENSP00000447731 | ENSP00000431548 | Transmembrane protein 116. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.546 |
TMEM179B | TMEM25 | ENSP00000333697 | ENSP00000431548 | Transmembrane protein 179B; Belongs to the TMEM179 family. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.544 |
TMEM207 | NDC1 | ENSP00000346981 | ENSP00000360483 | Transmembrane protein 207. | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. | 0.433 |