node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC18 | TMEM35B | ENSP00000343377 | ENSP00000362435 | Coiled-coil domain containing 18. | Transmembrane protein 35B. | 0.478 |
DDX42 | GPN2 | ENSP00000464050 | ENSP00000363250 | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | 0.491 |
DDX42 | TMEM35B | ENSP00000464050 | ENSP00000362435 | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] | Transmembrane protein 35B. | 0.466 |
DDX42 | UROS | ENSP00000464050 | ENSP00000357787 | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). | 0.445 |
GPN2 | DDX42 | ENSP00000363250 | ENSP00000464050 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] | 0.491 |
GPN2 | TMEM35B | ENSP00000363250 | ENSP00000362435 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | Transmembrane protein 35B. | 0.570 |
GPN2 | UROS | ENSP00000363250 | ENSP00000357787 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). | 0.464 |
TMEM35A | TMEM35B | ENSP00000362021 | ENSP00000362435 | Transmembrane protein 35A; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth. | Transmembrane protein 35B. | 0.480 |
TMEM35B | CCDC18 | ENSP00000362435 | ENSP00000343377 | Transmembrane protein 35B. | Coiled-coil domain containing 18. | 0.478 |
TMEM35B | DDX42 | ENSP00000362435 | ENSP00000464050 | Transmembrane protein 35B. | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] | 0.466 |
TMEM35B | GPN2 | ENSP00000362435 | ENSP00000363250 | Transmembrane protein 35B. | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | 0.570 |
TMEM35B | TMEM35A | ENSP00000362435 | ENSP00000362021 | Transmembrane protein 35B. | Transmembrane protein 35A; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth. | 0.480 |
TMEM35B | TOMM20L | ENSP00000362435 | ENSP00000354204 | Transmembrane protein 35B. | TOMM20-like protein 1; Translocase of outer mitochondrial membrane 20 like. | 0.527 |
TMEM35B | UROS | ENSP00000362435 | ENSP00000357787 | Transmembrane protein 35B. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). | 0.441 |
TMEM35B | ZMYM4 | ENSP00000362435 | ENSP00000322915 | Transmembrane protein 35B. | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.448 |
TMEM35B | ZMYM6 | ENSP00000362435 | ENSP00000349708 | Transmembrane protein 35B. | Zinc finger MYM-type protein 6; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.448 |
TOMM20L | TMEM35B | ENSP00000354204 | ENSP00000362435 | TOMM20-like protein 1; Translocase of outer mitochondrial membrane 20 like. | Transmembrane protein 35B. | 0.527 |
UROS | DDX42 | ENSP00000357787 | ENSP00000464050 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] | 0.445 |
UROS | GPN2 | ENSP00000357787 | ENSP00000363250 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | 0.464 |
UROS | TMEM35B | ENSP00000357787 | ENSP00000362435 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). | Transmembrane protein 35B. | 0.441 |