node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACBD6 | ASPHD2 | ENSP00000495710 | ENSP00000215906 | Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. | Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase. | 0.531 |
ACBD6 | B3GLCT | ENSP00000495710 | ENSP00000343002 | Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | 0.458 |
ACBD6 | TMEM53 | ENSP00000495710 | ENSP00000361311 | Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.552 |
ASPHD2 | ACBD6 | ENSP00000215906 | ENSP00000495710 | Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase. | Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. | 0.531 |
ASPHD2 | B3GLCT | ENSP00000215906 | ENSP00000343002 | Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase. | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | 0.467 |
ASPHD2 | TMEM53 | ENSP00000215906 | ENSP00000361311 | Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase. | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.576 |
B3GLCT | ACBD6 | ENSP00000343002 | ENSP00000495710 | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. | 0.458 |
B3GLCT | ASPHD2 | ENSP00000343002 | ENSP00000215906 | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase. | 0.467 |
B3GLCT | TMEM53 | ENSP00000343002 | ENSP00000361311 | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.490 |
ERI3 | RNF220 | ENSP00000361331 | ENSP00000347548 | ERI1 exoribonuclease family member 3. | E3 ubiquitin-protein ligase RNF220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 promoting Wnt signaling. | 0.545 |
ERI3 | TMEM53 | ENSP00000361331 | ENSP00000361311 | ERI1 exoribonuclease family member 3. | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.534 |
RBM28 | TMEM53 | ENSP00000223073 | ENSP00000361311 | RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes. | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.495 |
RNF220 | ERI3 | ENSP00000347548 | ENSP00000361331 | E3 ubiquitin-protein ligase RNF220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 promoting Wnt signaling. | ERI1 exoribonuclease family member 3. | 0.545 |
RNF220 | TMEM53 | ENSP00000347548 | ENSP00000361311 | E3 ubiquitin-protein ligase RNF220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 promoting Wnt signaling. | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.598 |
TMEM147 | TMEM223 | ENSP00000222284 | ENSP00000303987 | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. | Transmembrane protein 223. | 0.596 |
TMEM147 | TMEM238 | ENSP00000222284 | ENSP00000416154 | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. | Transmembrane protein 238. | 0.478 |
TMEM147 | TMEM53 | ENSP00000222284 | ENSP00000361311 | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.559 |
TMEM209 | TMEM53 | ENSP00000380747 | ENSP00000361311 | Transmembrane protein 209. | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.505 |
TMEM223 | TMEM147 | ENSP00000303987 | ENSP00000222284 | Transmembrane protein 223. | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. | 0.596 |
TMEM223 | TMEM238 | ENSP00000303987 | ENSP00000416154 | Transmembrane protein 223. | Transmembrane protein 238. | 0.524 |