node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP1B3 | TMEM98 | ENSP00000286371 | ENSP00000463245 | Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.547 |
BEST1 | MFRP | ENSP00000399709 | ENSP00000481824 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Membrane frizzled-related protein; May play a role in eye development. | 0.522 |
BEST1 | MYRF | ENSP00000399709 | ENSP00000278836 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | 0.832 |
BEST1 | PRSS56 | ENSP00000399709 | ENSP00000479745 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Serine protease 56; Serine protease required during eye development. | 0.544 |
BEST1 | TMEM98 | ENSP00000399709 | ENSP00000463245 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.562 |
MFRP | BEST1 | ENSP00000481824 | ENSP00000399709 | Membrane frizzled-related protein; May play a role in eye development. | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | 0.522 |
MFRP | PRSS56 | ENSP00000481824 | ENSP00000479745 | Membrane frizzled-related protein; May play a role in eye development. | Serine protease 56; Serine protease required during eye development. | 0.762 |
MFRP | TMEM98 | ENSP00000481824 | ENSP00000463245 | Membrane frizzled-related protein; May play a role in eye development. | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.724 |
MYRF | BEST1 | ENSP00000278836 | ENSP00000399709 | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | 0.832 |
MYRF | PRSS56 | ENSP00000278836 | ENSP00000479745 | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | Serine protease 56; Serine protease required during eye development. | 0.447 |
MYRF | TMEM98 | ENSP00000278836 | ENSP00000463245 | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.759 |
PRSS56 | BEST1 | ENSP00000479745 | ENSP00000399709 | Serine protease 56; Serine protease required during eye development. | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | 0.544 |
PRSS56 | MFRP | ENSP00000479745 | ENSP00000481824 | Serine protease 56; Serine protease required during eye development. | Membrane frizzled-related protein; May play a role in eye development. | 0.762 |
PRSS56 | MYRF | ENSP00000479745 | ENSP00000278836 | Serine protease 56; Serine protease required during eye development. | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | 0.447 |
PRSS56 | TMEM98 | ENSP00000479745 | ENSP00000463245 | Serine protease 56; Serine protease required during eye development. | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.810 |
STX7 | STX8 | ENSP00000356918 | ENSP00000305255 | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes; Belongs to the syntaxin family. | Syntaxin-8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis- Golgi membranes to the ER; Belongs to the syntaxin family. | 0.999 |
STX7 | TMEM98 | ENSP00000356918 | ENSP00000463245 | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes; Belongs to the syntaxin family. | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.618 |
STX7 | VAMP3 | ENSP00000356918 | ENSP00000054666 | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes; Belongs to the syntaxin family. | Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. | 0.981 |
STX7 | VAMP8 | ENSP00000356918 | ENSP00000263864 | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes; Belongs to the syntaxin family. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.999 |
STX8 | STX7 | ENSP00000305255 | ENSP00000356918 | Syntaxin-8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis- Golgi membranes to the ER; Belongs to the syntaxin family. | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes; Belongs to the syntaxin family. | 0.999 |