node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1QA | MS4A4A | ENSP00000363773 | ENSP00000338648 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Membrane-spanning 4-domains subfamily A member 4A; May be involved in signal transduction as a component of a multimeric receptor complex. | 0.803 |
C1QA | TMIGD3 | ENSP00000363773 | ENSP00000358730 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | 0.447 |
C1QA | VSIG4 | ENSP00000363773 | ENSP00000363869 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | V-set and immunoglobulin domain-containing protein 4; Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. | 0.971 |
C1QA | VWF | ENSP00000363773 | ENSP00000261405 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Von Willebrand antigen 2; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. | 0.487 |
EVI2A | TMIGD3 | ENSP00000247270 | ENSP00000358730 | Protein EVI2A; May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor. | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | 0.438 |
FAM124A | TMIGD3 | ENSP00000280057 | ENSP00000358730 | Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family. | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | 0.470 |
MS4A4A | C1QA | ENSP00000338648 | ENSP00000363773 | Membrane-spanning 4-domains subfamily A member 4A; May be involved in signal transduction as a component of a multimeric receptor complex. | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | 0.803 |
MS4A4A | TMIGD3 | ENSP00000338648 | ENSP00000358730 | Membrane-spanning 4-domains subfamily A member 4A; May be involved in signal transduction as a component of a multimeric receptor complex. | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | 0.482 |
MS4A4A | VSIG4 | ENSP00000338648 | ENSP00000363869 | Membrane-spanning 4-domains subfamily A member 4A; May be involved in signal transduction as a component of a multimeric receptor complex. | V-set and immunoglobulin domain-containing protein 4; Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. | 0.958 |
TMIGD1 | TMIGD3 | ENSP00000332404 | ENSP00000358730 | Transmembrane and immunoglobulin domain-containing protein 1; May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival. | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | 0.583 |
TMIGD3 | C1QA | ENSP00000358730 | ENSP00000363773 | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | 0.447 |
TMIGD3 | EVI2A | ENSP00000358730 | ENSP00000247270 | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | Protein EVI2A; May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor. | 0.438 |
TMIGD3 | FAM124A | ENSP00000358730 | ENSP00000280057 | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family. | 0.470 |
TMIGD3 | MS4A4A | ENSP00000358730 | ENSP00000338648 | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | Membrane-spanning 4-domains subfamily A member 4A; May be involved in signal transduction as a component of a multimeric receptor complex. | 0.482 |
TMIGD3 | TMIGD1 | ENSP00000358730 | ENSP00000332404 | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | Transmembrane and immunoglobulin domain-containing protein 1; May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival. | 0.583 |
TMIGD3 | VSIG4 | ENSP00000358730 | ENSP00000363869 | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | V-set and immunoglobulin domain-containing protein 4; Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. | 0.764 |
TMIGD3 | VWF | ENSP00000358730 | ENSP00000261405 | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | Von Willebrand antigen 2; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. | 0.401 |
VSIG4 | C1QA | ENSP00000363869 | ENSP00000363773 | V-set and immunoglobulin domain-containing protein 4; Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | 0.971 |
VSIG4 | MS4A4A | ENSP00000363869 | ENSP00000338648 | V-set and immunoglobulin domain-containing protein 4; Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. | Membrane-spanning 4-domains subfamily A member 4A; May be involved in signal transduction as a component of a multimeric receptor complex. | 0.958 |
VSIG4 | TMIGD3 | ENSP00000363869 | ENSP00000358730 | V-set and immunoglobulin domain-containing protein 4; Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. | Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. | 0.764 |