node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C4orf45 | TNFAIP8L1 | ENSP00000412215 | ENSP00000444215 | Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45. | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | 0.499 |
CASP10 | TNFAIP8L1 | ENSP00000286186 | ENSP00000444215 | Caspase-10 subunit p23/17; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform C is proteolytically inactive. Belongs to the peptidase C14A family. | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | 0.474 |
FBXW5 | POMP | ENSP00000313034 | ENSP00000370222 | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] | Proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum; Belongs to the POMP/UMP1 family. | 0.404 |
FBXW5 | TNFAIP8L1 | ENSP00000313034 | ENSP00000444215 | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | 0.737 |
POMP | FBXW5 | ENSP00000370222 | ENSP00000313034 | Proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum; Belongs to the POMP/UMP1 family. | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] | 0.404 |
POMP | TNFAIP8L1 | ENSP00000370222 | ENSP00000444215 | Proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum; Belongs to the POMP/UMP1 family. | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | 0.648 |
PPP1R14C | PRTFDC1 | ENSP00000355260 | ENSP00000318602 | Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA. | Phosphoribosyltransferase domain-containing protein 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.433 |
PPP1R14C | TNFAIP8L1 | ENSP00000355260 | ENSP00000444215 | Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA. | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | 0.444 |
PRTFDC1 | PPP1R14C | ENSP00000318602 | ENSP00000355260 | Phosphoribosyltransferase domain-containing protein 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA. | 0.433 |
PRTFDC1 | TNFAIP8L1 | ENSP00000318602 | ENSP00000444215 | Phosphoribosyltransferase domain-containing protein 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | 0.428 |
TNFAIP8L1 | C4orf45 | ENSP00000444215 | ENSP00000412215 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45. | 0.499 |
TNFAIP8L1 | CASP10 | ENSP00000444215 | ENSP00000286186 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | Caspase-10 subunit p23/17; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform C is proteolytically inactive. Belongs to the peptidase C14A family. | 0.474 |
TNFAIP8L1 | FBXW5 | ENSP00000444215 | ENSP00000313034 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] | 0.737 |
TNFAIP8L1 | POMP | ENSP00000444215 | ENSP00000370222 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | Proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum; Belongs to the POMP/UMP1 family. | 0.648 |
TNFAIP8L1 | PPP1R14C | ENSP00000444215 | ENSP00000355260 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA. | 0.444 |
TNFAIP8L1 | PRTFDC1 | ENSP00000444215 | ENSP00000318602 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family. | Phosphoribosyltransferase domain-containing protein 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.428 |