node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | BGN | ENSP00000387356 | ENSP00000327336 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | Biglycan; May be involved in collagen fiber assembly. | 0.928 |
ACAN | COL1A1 | ENSP00000387356 | ENSP00000225964 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.835 |
ACAN | DCN | ENSP00000387356 | ENSP00000052754 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | Decorin; May affect the rate of fibrils formation. | 0.962 |
ACAN | FMOD | ENSP00000387356 | ENSP00000347041 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.953 |
ACAN | MKX | ENSP00000387356 | ENSP00000364946 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | Homeobox protein Mohawk; May act as a morphogenetic regulator of cell adhesion. Belongs to the TALE/IRO homeobox family. | 0.472 |
ACAN | SCX | ENSP00000387356 | ENSP00000476384 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | Basic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. | 0.446 |
ACAN | THBS4 | ENSP00000387356 | ENSP00000339730 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | Thrombospondin-4; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via it [...] | 0.483 |
ACAN | TNMD | ENSP00000387356 | ENSP00000362122 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | Tenomodulin; May be an angiogenesis inhibitor. | 0.649 |
BGN | ACAN | ENSP00000327336 | ENSP00000387356 | Biglycan; May be involved in collagen fiber assembly. | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | 0.928 |
BGN | COL1A1 | ENSP00000327336 | ENSP00000225964 | Biglycan; May be involved in collagen fiber assembly. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.974 |
BGN | DCN | ENSP00000327336 | ENSP00000052754 | Biglycan; May be involved in collagen fiber assembly. | Decorin; May affect the rate of fibrils formation. | 0.989 |
BGN | FMOD | ENSP00000327336 | ENSP00000347041 | Biglycan; May be involved in collagen fiber assembly. | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.976 |
BGN | MKX | ENSP00000327336 | ENSP00000364946 | Biglycan; May be involved in collagen fiber assembly. | Homeobox protein Mohawk; May act as a morphogenetic regulator of cell adhesion. Belongs to the TALE/IRO homeobox family. | 0.542 |
BGN | SCX | ENSP00000327336 | ENSP00000476384 | Biglycan; May be involved in collagen fiber assembly. | Basic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. | 0.412 |
BGN | THBS4 | ENSP00000327336 | ENSP00000339730 | Biglycan; May be involved in collagen fiber assembly. | Thrombospondin-4; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via it [...] | 0.536 |
BGN | TNMD | ENSP00000327336 | ENSP00000362122 | Biglycan; May be involved in collagen fiber assembly. | Tenomodulin; May be an angiogenesis inhibitor. | 0.673 |
COL1A1 | ACAN | ENSP00000225964 | ENSP00000387356 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | 0.835 |
COL1A1 | BGN | ENSP00000225964 | ENSP00000327336 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Biglycan; May be involved in collagen fiber assembly. | 0.974 |
COL1A1 | DCN | ENSP00000225964 | ENSP00000052754 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Decorin; May affect the rate of fibrils formation. | 0.923 |
COL1A1 | FMOD | ENSP00000225964 | ENSP00000347041 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.792 |