node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGR2 | TSPAN1 | ENSP00000391490 | ENSP00000361072 | Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion. | Tetraspanin-1; Tetraspanin 1. | 0.592 |
AGR2 | TSPAN13 | ENSP00000391490 | ENSP00000262067 | Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion. | Tetraspanin-13; Tetraspanin 13. | 0.425 |
CDHR1 | TM4SF1 | ENSP00000485478 | ENSP00000304277 | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). | Transmembrane 4 L six family member 1; Belongs to the L6 tetraspanin family. | 0.548 |
CDHR1 | TM4SF5 | ENSP00000485478 | ENSP00000270560 | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). | Transmembrane 4 L6 family member 5; Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4- CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression ; Belongs to the L6 tetraspanin family. | 0.784 |
CDHR1 | TSPAN1 | ENSP00000485478 | ENSP00000361072 | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). | Tetraspanin-1; Tetraspanin 1. | 0.566 |
CMTM1 | TSPAN1 | ENSP00000368814 | ENSP00000361072 | CKLF like MARVEL transmembrane domain containing 1. | Tetraspanin-1; Tetraspanin 1. | 0.570 |
ITGB1 | TM4SF1 | ENSP00000379350 | ENSP00000304277 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | Transmembrane 4 L six family member 1; Belongs to the L6 tetraspanin family. | 0.680 |
ITGB1 | TSPAN1 | ENSP00000379350 | ENSP00000361072 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | Tetraspanin-1; Tetraspanin 1. | 0.507 |
ITGB1 | TSPAN13 | ENSP00000379350 | ENSP00000262067 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | Tetraspanin-13; Tetraspanin 13. | 0.566 |
PTGFRN | TSPAN1 | ENSP00000376899 | ENSP00000361072 | Prostaglandin F2 receptor negative regulator; Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity). | Tetraspanin-1; Tetraspanin 1. | 0.561 |
SLC19A2 | TSPAN1 | ENSP00000236137 | ENSP00000361072 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Tetraspanin-1; Tetraspanin 1. | 0.749 |
TM4SF1 | CDHR1 | ENSP00000304277 | ENSP00000485478 | Transmembrane 4 L six family member 1; Belongs to the L6 tetraspanin family. | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). | 0.548 |
TM4SF1 | ITGB1 | ENSP00000304277 | ENSP00000379350 | Transmembrane 4 L six family member 1; Belongs to the L6 tetraspanin family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.680 |
TM4SF1 | TSPAN1 | ENSP00000304277 | ENSP00000361072 | Transmembrane 4 L six family member 1; Belongs to the L6 tetraspanin family. | Tetraspanin-1; Tetraspanin 1. | 0.802 |
TM4SF1 | TSPAN31 | ENSP00000304277 | ENSP00000257910 | Transmembrane 4 L six family member 1; Belongs to the L6 tetraspanin family. | Tetraspanin-31; Tetraspanin 31. | 0.632 |
TM4SF5 | CDHR1 | ENSP00000270560 | ENSP00000485478 | Transmembrane 4 L6 family member 5; Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4- CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression ; Belongs to the L6 tetraspanin family. | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). | 0.784 |
TM4SF5 | TSPAN1 | ENSP00000270560 | ENSP00000361072 | Transmembrane 4 L6 family member 5; Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4- CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression ; Belongs to the L6 tetraspanin family. | Tetraspanin-1; Tetraspanin 1. | 0.806 |
TSPAN1 | AGR2 | ENSP00000361072 | ENSP00000391490 | Tetraspanin-1; Tetraspanin 1. | Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion. | 0.592 |
TSPAN1 | CDHR1 | ENSP00000361072 | ENSP00000485478 | Tetraspanin-1; Tetraspanin 1. | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). | 0.566 |
TSPAN1 | CMTM1 | ENSP00000361072 | ENSP00000368814 | Tetraspanin-1; Tetraspanin 1. | CKLF like MARVEL transmembrane domain containing 1. | 0.570 |