STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSPAN18Tetraspanin-18; Tetraspanin 18; Tetraspanins (248 aa)    
Predicted Functional Partners:
GHITM
Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c; Transmembrane BAX inhibitor motif containing
      
 0.651
PICK1
PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...]
      
 0.608
TSPAN32
Tetraspanin-32; Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family
      
 0.591
NKAPL
NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis
      
 0.589
ZSCAN31
Zinc finger and SCAN domain-containing protein 31; May function as a transcription factor. May be involved in the development of multiple embryonic organs; Belongs to the krueppel C2H2-type zinc-finger protein family
      
 0.556
ZKSCAN4
Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family
      
 0.537
RNF130
E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin- protein ligase; Ring finger proteins
    
   0.527
TSPAN19
Putative tetraspanin-19; Tetraspanin 19; Tetraspanins
      
 0.476
CD300LG
CMRF35-like molecule 9; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity); V-set domain containing
      
 0.461
TSPAN13
Tetraspanin-13; Tetraspanin 13; Tetraspanins
      
 0.455
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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