node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C9orf116 | TEKT3 | ENSP00000395281 | ENSP00000379263 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. | 0.862 |
C9orf116 | VWA2 | ENSP00000395281 | ENSP00000376708 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | Von Willebrand factor A domain containing 2. | 0.494 |
CATIP | VWA2 | ENSP00000289388 | ENSP00000376708 | Ciliogenesis-associated TTC17-interacting protein; Plays a role in primary ciliogenesis by modulating actin polymerization. | Von Willebrand factor A domain containing 2. | 0.461 |
CEMIP | VWA2 | ENSP00000378177 | ENSP00000376708 | Cell migration-inducing and hyaluronan-binding protein; Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tum [...] | Von Willebrand factor A domain containing 2. | 0.494 |
FREM1 | FREM2 | ENSP00000412940 | ENSP00000280481 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs. Belongs to the FRAS1 family. | 0.994 |
FREM1 | VWA2 | ENSP00000412940 | ENSP00000376708 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Von Willebrand factor A domain containing 2. | 0.594 |
FREM2 | FREM1 | ENSP00000280481 | ENSP00000412940 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs. Belongs to the FRAS1 family. | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | 0.994 |
FREM2 | VWA2 | ENSP00000280481 | ENSP00000376708 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs. Belongs to the FRAS1 family. | Von Willebrand factor A domain containing 2. | 0.478 |
NHLRC2 | VWA2 | ENSP00000358307 | ENSP00000376708 | NHL repeat-containing protein 2; Required for normal embryonic development. | Von Willebrand factor A domain containing 2. | 0.581 |
SPAG17 | TEKT3 | ENSP00000337804 | ENSP00000379263 | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. | 0.630 |
SPAG17 | VWA2 | ENSP00000337804 | ENSP00000376708 | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | Von Willebrand factor A domain containing 2. | 0.461 |
SPATA31D3 | VWA2 | ENSP00000488117 | ENSP00000376708 | Spermatogenesis-associated protein 31D3; May play a role in spermatogenesis; Belongs to the SPATA31 family. | Von Willebrand factor A domain containing 2. | 0.474 |
TDRD1 | VWA2 | ENSP00000251864 | ENSP00000376708 | Tudor domain-containing protein 1; Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of corr [...] | Von Willebrand factor A domain containing 2. | 0.498 |
TEKT3 | C9orf116 | ENSP00000379263 | ENSP00000395281 | Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | 0.862 |
TEKT3 | SPAG17 | ENSP00000379263 | ENSP00000337804 | Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.630 |
TEKT3 | VWA2 | ENSP00000379263 | ENSP00000376708 | Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. | Von Willebrand factor A domain containing 2. | 0.461 |
VWA2 | C9orf116 | ENSP00000376708 | ENSP00000395281 | Von Willebrand factor A domain containing 2. | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | 0.494 |
VWA2 | CATIP | ENSP00000376708 | ENSP00000289388 | Von Willebrand factor A domain containing 2. | Ciliogenesis-associated TTC17-interacting protein; Plays a role in primary ciliogenesis by modulating actin polymerization. | 0.461 |
VWA2 | CEMIP | ENSP00000376708 | ENSP00000378177 | Von Willebrand factor A domain containing 2. | Cell migration-inducing and hyaluronan-binding protein; Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tum [...] | 0.494 |
VWA2 | FREM1 | ENSP00000376708 | ENSP00000412940 | Von Willebrand factor A domain containing 2. | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | 0.594 |