node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PARG | VWA5A | ENSP00000384408 | ENSP00000407726 | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental ac [...] | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | 0.418 |
PKNOX1 | VWA5A | ENSP00000291547 | ENSP00000407726 | Homeobox protein PKNOX1; Activates transcription in the presence of PBX1A and HOXA1. | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | 0.624 |
PKNOX2 | VWA5A | ENSP00000298282 | ENSP00000407726 | Homeobox protein PKNOX2; PBX/knotted 1 homeobox 2; Belongs to the TALE/MEIS homeobox family. | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | 0.547 |
PXMP2 | SNX15 | ENSP00000321271 | ENSP00000366452 | Peroxisomal membrane protein 2; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane. | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | 0.482 |
PXMP2 | VWA5A | ENSP00000321271 | ENSP00000407726 | Peroxisomal membrane protein 2; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane. | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | 0.436 |
RNF150 | SNX15 | ENSP00000425840 | ENSP00000366452 | Ring finger protein 150. | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | 0.487 |
RNF150 | TMEM63C | ENSP00000425840 | ENSP00000298351 | Ring finger protein 150. | Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Belongs to the CSC1 (TC 1.A.17) family. | 0.456 |
RNF150 | VWA5A | ENSP00000425840 | ENSP00000407726 | Ring finger protein 150. | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | 0.460 |
SNX15 | PXMP2 | ENSP00000366452 | ENSP00000321271 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | Peroxisomal membrane protein 2; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane. | 0.482 |
SNX15 | RNF150 | ENSP00000366452 | ENSP00000425840 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | Ring finger protein 150. | 0.487 |
SNX15 | TMEM63C | ENSP00000366452 | ENSP00000298351 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Belongs to the CSC1 (TC 1.A.17) family. | 0.463 |
SNX15 | VWA5A | ENSP00000366452 | ENSP00000407726 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | 0.475 |
SOX10 | VWA5A | ENSP00000380093 | ENSP00000407726 | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | 0.663 |
SPDYE6 | VWA5A | ENSP00000485230 | ENSP00000407726 | Speedy protein E6; speedy/RINGO cell cycle regulator family member E6; Belongs to the Speedy/Ringo family. | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | 0.507 |
TMEM63C | RNF150 | ENSP00000298351 | ENSP00000425840 | Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Belongs to the CSC1 (TC 1.A.17) family. | Ring finger protein 150. | 0.456 |
TMEM63C | SNX15 | ENSP00000298351 | ENSP00000366452 | Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Belongs to the CSC1 (TC 1.A.17) family. | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | 0.463 |
TMEM63C | VWA5A | ENSP00000298351 | ENSP00000407726 | Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Belongs to the CSC1 (TC 1.A.17) family. | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | 0.458 |
TUT4 | VWA5A | ENSP00000257177 | ENSP00000407726 | Terminal uridylyltransferase 4; Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation [...] | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | 0.480 |
VWA5A | PARG | ENSP00000407726 | ENSP00000384408 | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental ac [...] | 0.418 |
VWA5A | PKNOX1 | ENSP00000407726 | ENSP00000291547 | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. | Homeobox protein PKNOX1; Activates transcription in the presence of PBX1A and HOXA1. | 0.624 |