STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
XAGE1AX antigen family member 1A. (81 aa)    
Predicted Functional Partners:
XAGE1B
X antigen family member 1B.
   
  
0.999
XAGE3
X antigen family member 3.
      
 0.947
XAGE2
X antigen family member 2.
      
 0.923
MAGEC1
Melanoma-associated antigen C1; MAGE family member C1.
   
  
 0.744
CTAG1B
Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family.
   
  
 0.676
MAGEA1
Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
   
  
 0.619
CT45A1
Cancer/testis antigen family 45 member A1.
   
  
 0.611
GAGE2A
G antigen 2A.
   
  
 0.606
GAGE1
G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family.
   
  
 0.594
ADAM29
Disintegrin and metalloproteinase domain-containing protein 29; May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.
      
 0.557
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.