STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
XAGE2X antigen family member 2. (111 aa)    
Predicted Functional Partners:
XAGE1A
X antigen family member 1A.
      
 0.923
XAGE1B
X antigen family member 1B.
      
 0.886
GMCL1
Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).
    
   0.719
ZNF462
Zinc finger protein 462; Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation.
    
   0.610
SPANXC
Sperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family.
   
  
 0.572
SPANXD
Sperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family.
      
 0.570
FOXP4
Forkhead box protein P4; Transcriptional repressor that represses lung-specific expression.
    
   0.457
SPANXB1
Sperm protein associated with the nucleus on the X chromosome B1; SPANX family member B1.
   
  
 0.455
ERVV-1
Endogenous retrovirus group V member 1, envelope; Belongs to the gamma type-C retroviral envelope protein family.
      
 0.448
SPANXA2
Sperm protein associated with the nucleus on the X chromosome A; SPANX family member A2; Belongs to the SPAN-X family.
      
 0.447
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.