node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTN1A1 | BTN2A1 | ENSP00000244513 | ENSP00000312158 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family. | Butyrophilin subfamily 2 member A1. | 0.483 |
BTN1A1 | XDH | ENSP00000244513 | ENSP00000368727 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family. | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). | 0.998 |
BTN2A1 | BTN1A1 | ENSP00000312158 | ENSP00000244513 | Butyrophilin subfamily 2 member A1. | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.483 |
BTN2A1 | BTN2A2 | ENSP00000312158 | ENSP00000349143 | Butyrophilin subfamily 2 member A1. | Butyrophilin subfamily 2 member A2; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.681 |
BTN2A1 | BTNL3 | ENSP00000312158 | ENSP00000341787 | Butyrophilin subfamily 2 member A1. | Butyrophilin-like protein 3; Butyrophilin like 3. | 0.413 |
BTN2A1 | BTNL8 | ENSP00000312158 | ENSP00000342197 | Butyrophilin subfamily 2 member A1. | Butyrophilin-like protein 8; May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production; Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.423 |
BTN2A1 | BTNL9 | ENSP00000312158 | ENSP00000330200 | Butyrophilin subfamily 2 member A1. | Butyrophilin-like protein 9; Butyrophilin like 9; Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.443 |
BTN2A1 | XDH | ENSP00000312158 | ENSP00000368727 | Butyrophilin subfamily 2 member A1. | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). | 0.988 |
BTN2A2 | BTN2A1 | ENSP00000349143 | ENSP00000312158 | Butyrophilin subfamily 2 member A2; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Belongs to the immunoglobulin superfamily. BTN/MOG family. | Butyrophilin subfamily 2 member A1. | 0.681 |
BTN2A2 | XDH | ENSP00000349143 | ENSP00000368727 | Butyrophilin subfamily 2 member A2; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Belongs to the immunoglobulin superfamily. BTN/MOG family. | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). | 0.988 |
BTNL3 | BTN2A1 | ENSP00000341787 | ENSP00000312158 | Butyrophilin-like protein 3; Butyrophilin like 3. | Butyrophilin subfamily 2 member A1. | 0.413 |
BTNL3 | BTNL8 | ENSP00000341787 | ENSP00000342197 | Butyrophilin-like protein 3; Butyrophilin like 3. | Butyrophilin-like protein 8; May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production; Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.467 |
BTNL3 | XDH | ENSP00000341787 | ENSP00000368727 | Butyrophilin-like protein 3; Butyrophilin like 3. | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). | 0.969 |
BTNL8 | BTN2A1 | ENSP00000342197 | ENSP00000312158 | Butyrophilin-like protein 8; May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Butyrophilin subfamily 2 member A1. | 0.423 |
BTNL8 | BTNL3 | ENSP00000342197 | ENSP00000341787 | Butyrophilin-like protein 8; May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Butyrophilin-like protein 3; Butyrophilin like 3. | 0.467 |
BTNL8 | XDH | ENSP00000342197 | ENSP00000368727 | Butyrophilin-like protein 8; May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). | 0.969 |
BTNL9 | BTN2A1 | ENSP00000330200 | ENSP00000312158 | Butyrophilin-like protein 9; Butyrophilin like 9; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Butyrophilin subfamily 2 member A1. | 0.443 |
BTNL9 | XDH | ENSP00000330200 | ENSP00000368727 | Butyrophilin-like protein 9; Butyrophilin like 9; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). | 0.988 |
ERMAP | XDH | ENSP00000361595 | ENSP00000368727 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). | 0.969 |
GDA | PNP | ENSP00000238018 | ENSP00000354532 | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.991 |