node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BEND3 | ZBTB10 | ENSP00000411268 | ENSP00000387462 | BEN domain-containing protein 3; Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities. | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | 0.425 |
BRCA1 | TERF2 | ENSP00000418960 | ENSP00000254942 | Breast cancer type 1 susceptibility protein; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic [...] | Telomeric repeat-binding factor 2; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA- binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'- TTAGGG-3' repeats added [...] | 0.935 |
BRCA1 | ZBTB10 | ENSP00000418960 | ENSP00000387462 | Breast cancer type 1 susceptibility protein; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic [...] | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | 0.437 |
CCL27 | ZBTB10 | ENSP00000259631 | ENSP00000387462 | C-C motif chemokine 27; Chemotactic factor that attracts skin-associated memory T- lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10. | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | 0.422 |
FBXL17 | ZBTB10 | ENSP00000437464 | ENSP00000387462 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB di [...] | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | 0.566 |
FBXL17 | ZBTB46 | ENSP00000437464 | ENSP00000378536 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB di [...] | Zinc finger and BTB domain-containing protein 46; Functions as a transcriptional repressor for PRDM1. | 0.434 |
HPS1 | ZBTB10 | ENSP00000326649 | ENSP00000387462 | Hermansky-Pudlak syndrome 1 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | 0.463 |
KLHL29 | ZBTB10 | ENSP00000420659 | ENSP00000387462 | Kelch-like protein 29; Kelch like family member 29. | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | 0.457 |
RFPL4B | ZBTB10 | ENSP00000423391 | ENSP00000387462 | Ret finger protein like 4B. | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | 0.426 |
TERF2 | BRCA1 | ENSP00000254942 | ENSP00000418960 | Telomeric repeat-binding factor 2; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA- binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'- TTAGGG-3' repeats added [...] | Breast cancer type 1 susceptibility protein; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic [...] | 0.935 |
TERF2 | ZBTB10 | ENSP00000254942 | ENSP00000387462 | Telomeric repeat-binding factor 2; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA- binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'- TTAGGG-3' repeats added [...] | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | 0.455 |
ZBTB10 | BEND3 | ENSP00000387462 | ENSP00000411268 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | BEN domain-containing protein 3; Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities. | 0.425 |
ZBTB10 | BRCA1 | ENSP00000387462 | ENSP00000418960 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | Breast cancer type 1 susceptibility protein; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic [...] | 0.437 |
ZBTB10 | CCL27 | ENSP00000387462 | ENSP00000259631 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | C-C motif chemokine 27; Chemotactic factor that attracts skin-associated memory T- lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10. | 0.422 |
ZBTB10 | FBXL17 | ENSP00000387462 | ENSP00000437464 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB di [...] | 0.566 |
ZBTB10 | HPS1 | ENSP00000387462 | ENSP00000326649 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | Hermansky-Pudlak syndrome 1 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. | 0.463 |
ZBTB10 | KLHL29 | ENSP00000387462 | ENSP00000420659 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | Kelch-like protein 29; Kelch like family member 29. | 0.457 |
ZBTB10 | RFPL4B | ENSP00000387462 | ENSP00000423391 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | Ret finger protein like 4B. | 0.426 |
ZBTB10 | TERF2 | ENSP00000387462 | ENSP00000254942 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | Telomeric repeat-binding factor 2; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA- binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'- TTAGGG-3' repeats added [...] | 0.455 |
ZBTB10 | ZBTB46 | ENSP00000387462 | ENSP00000378536 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. | Zinc finger and BTB domain-containing protein 46; Functions as a transcriptional repressor for PRDM1. | 0.421 |