node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA8 | MFAP4 | ENSP00000467271 | ENSP00000378957 | ATP-binding cassette sub-family A member 8; ATP-dependent lipophilic drug transporter. | Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. | 0.501 |
ABCA8 | ZCCHC24 | ENSP00000467271 | ENSP00000361411 | ATP-binding cassette sub-family A member 8; ATP-dependent lipophilic drug transporter. | Zinc finger CCHC-type containing 24. | 0.466 |
COL14A1 | MFAP4 | ENSP00000297848 | ENSP00000378957 | Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). | Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. | 0.710 |
COL14A1 | ZCCHC24 | ENSP00000297848 | ENSP00000361411 | Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). | Zinc finger CCHC-type containing 24. | 0.434 |
COL14A1 | ZNF423 | ENSP00000297848 | ENSP00000455426 | Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmenta [...] | 0.425 |
DYDC2 | ZCCHC24 | ENSP00000361272 | ENSP00000361411 | DPY30 domain containing 2; Belongs to the dpy-30 family. | Zinc finger CCHC-type containing 24. | 0.440 |
ESRP1 | RBM47 | ENSP00000405738 | ENSP00000295971 | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes [...] | RNA binding motif protein 47; Belongs to the RRM RBM47 family. | 0.560 |
ESRP1 | ZCCHC24 | ENSP00000405738 | ENSP00000361411 | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes [...] | Zinc finger CCHC-type containing 24. | 0.452 |
FAM126A | TMEM109 | ENSP00000403396 | ENSP00000227525 | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta- catenin/Lef signaling pathway (Probable). | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity). | 0.454 |
FAM126A | ZCCHC24 | ENSP00000403396 | ENSP00000361411 | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta- catenin/Lef signaling pathway (Probable). | Zinc finger CCHC-type containing 24. | 0.444 |
MFAP4 | ABCA8 | ENSP00000378957 | ENSP00000467271 | Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. | ATP-binding cassette sub-family A member 8; ATP-dependent lipophilic drug transporter. | 0.501 |
MFAP4 | COL14A1 | ENSP00000378957 | ENSP00000297848 | Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. | Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). | 0.710 |
MFAP4 | ZCCHC24 | ENSP00000378957 | ENSP00000361411 | Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. | Zinc finger CCHC-type containing 24. | 0.566 |
MFAP4 | ZNF423 | ENSP00000378957 | ENSP00000455426 | Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmenta [...] | 0.437 |
RBM47 | ESRP1 | ENSP00000295971 | ENSP00000405738 | RNA binding motif protein 47; Belongs to the RRM RBM47 family. | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes [...] | 0.560 |
RBM47 | ZCCHC24 | ENSP00000295971 | ENSP00000361411 | RNA binding motif protein 47; Belongs to the RRM RBM47 family. | Zinc finger CCHC-type containing 24. | 0.670 |
SH3RF3 | ZCCHC24 | ENSP00000309186 | ENSP00000361411 | E3 ubiquitin-protein ligase SH3RF3; Has E3 ubiquitin-protein ligase activity. | Zinc finger CCHC-type containing 24. | 0.477 |
TMEM109 | FAM126A | ENSP00000227525 | ENSP00000403396 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity). | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta- catenin/Lef signaling pathway (Probable). | 0.454 |
TMEM109 | ZCCHC24 | ENSP00000227525 | ENSP00000361411 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity). | Zinc finger CCHC-type containing 24. | 0.487 |
ZCCHC24 | ABCA8 | ENSP00000361411 | ENSP00000467271 | Zinc finger CCHC-type containing 24. | ATP-binding cassette sub-family A member 8; ATP-dependent lipophilic drug transporter. | 0.466 |