node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM110A | ZDHHC18 | ENSP00000354163 | ENSP00000363257 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.479 |
GOLGA7 | ZDHHC18 | ENSP00000350378 | ENSP00000363257 | Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.400 |
IL9R | ZDHHC18 | ENSP00000244174 | ENSP00000363257 | Interleukin-9 receptor; This is a receptor for interleukin-9; Belongs to the type I cytokine receptor family. Type 4 subfamily. | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.435 |
LYPLA1 | PPT2 | ENSP00000320043 | ENSP00000354608 | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. | 0.543 |
LYPLA1 | ZDHHC18 | ENSP00000320043 | ENSP00000363257 | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.419 |
LYPLA1 | ZDHHC23 | ENSP00000320043 | ENSP00000498556 | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. | 0.466 |
LYPLA2 | PPT2 | ENSP00000363638 | ENSP00000354608 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity). | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. | 0.532 |
LYPLA2 | ZDHHC18 | ENSP00000363638 | ENSP00000363257 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity). | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.457 |
LYPLA2 | ZDHHC23 | ENSP00000363638 | ENSP00000498556 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity). | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. | 0.490 |
PPT2 | LYPLA1 | ENSP00000354608 | ENSP00000320043 | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.543 |
PPT2 | LYPLA2 | ENSP00000354608 | ENSP00000363638 | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity). | 0.532 |
PPT2 | ZDHHC18 | ENSP00000354608 | ENSP00000363257 | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.410 |
RNF144A | ZDHHC18 | ENSP00000321330 | ENSP00000363257 | E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC; Belongs to the RBR family. RNF144 subfamily. | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.494 |
UPF1 | ZDHHC18 | ENSP00000470142 | ENSP00000363257 | Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more n [...] | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.408 |
ZDHHC18 | FAM110A | ENSP00000363257 | ENSP00000354163 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. | 0.479 |
ZDHHC18 | GOLGA7 | ENSP00000363257 | ENSP00000350378 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. | 0.400 |
ZDHHC18 | IL9R | ENSP00000363257 | ENSP00000244174 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | Interleukin-9 receptor; This is a receptor for interleukin-9; Belongs to the type I cytokine receptor family. Type 4 subfamily. | 0.435 |
ZDHHC18 | LYPLA1 | ENSP00000363257 | ENSP00000320043 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.419 |
ZDHHC18 | LYPLA2 | ENSP00000363257 | ENSP00000363638 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity). | 0.457 |
ZDHHC18 | PPT2 | ENSP00000363257 | ENSP00000354608 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. | 0.410 |