node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP5B1 | AP5S1 | ENSP00000454303 | ENSP00000481750 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is required for efficient homologous recombination DNA double-strand break repair. | 0.999 |
AP5B1 | AP5Z1 | ENSP00000454303 | ENSP00000497815 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | 0.998 |
AP5B1 | SPG11 | ENSP00000454303 | ENSP00000261866 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. | 0.980 |
AP5B1 | ZFYVE26 | ENSP00000454303 | ENSP00000251119 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. | 0.909 |
AP5S1 | AP5B1 | ENSP00000481750 | ENSP00000454303 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is required for efficient homologous recombination DNA double-strand break repair. | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | 0.999 |
AP5S1 | AP5Z1 | ENSP00000481750 | ENSP00000497815 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is required for efficient homologous recombination DNA double-strand break repair. | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | 0.997 |
AP5S1 | SPG11 | ENSP00000481750 | ENSP00000261866 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is required for efficient homologous recombination DNA double-strand break repair. | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. | 0.961 |
AP5S1 | ZFYVE26 | ENSP00000481750 | ENSP00000251119 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is required for efficient homologous recombination DNA double-strand break repair. | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. | 0.948 |
AP5Z1 | AP5B1 | ENSP00000497815 | ENSP00000454303 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | 0.998 |
AP5Z1 | AP5S1 | ENSP00000497815 | ENSP00000481750 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is required for efficient homologous recombination DNA double-strand break repair. | 0.997 |
AP5Z1 | ATL1 | ENSP00000497815 | ENSP00000351155 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | 0.480 |
AP5Z1 | SPAST | ENSP00000497815 | ENSP00000320885 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.608 |
AP5Z1 | SPG11 | ENSP00000497815 | ENSP00000261866 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. | 0.996 |
AP5Z1 | SPG21 | ENSP00000497815 | ENSP00000204566 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.868 |
AP5Z1 | WASHC5 | ENSP00000497815 | ENSP00000318016 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7. | 0.623 |
AP5Z1 | ZFYVE26 | ENSP00000497815 | ENSP00000251119 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. | 0.992 |
ATL1 | AP5Z1 | ENSP00000351155 | ENSP00000497815 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. | 0.480 |
ATL1 | SPAST | ENSP00000351155 | ENSP00000320885 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.996 |
ATL1 | SPG11 | ENSP00000351155 | ENSP00000261866 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. | 0.733 |
ATL1 | SPG21 | ENSP00000351155 | ENSP00000204566 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.577 |