node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HMGN4 | POM121L2 | ENSP00000366798 | ENSP00000392726 | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family. | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | 0.472 |
HMGN4 | ZNF184 | ENSP00000366798 | ENSP00000211936 | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family. | Zinc finger protein 184; May be involved in transcriptional regulation. | 0.416 |
ITPKB | ZNF184 | ENSP00000411152 | ENSP00000211936 | Inositol-trisphosphate 3-kinase B. | Zinc finger protein 184; May be involved in transcriptional regulation. | 0.430 |
PDIK1L | ZNF184 | ENSP00000363389 | ENSP00000211936 | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like. | Zinc finger protein 184; May be involved in transcriptional regulation. | 0.538 |
POM121L2 | HMGN4 | ENSP00000392726 | ENSP00000366798 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family. | 0.472 |
POM121L2 | PRSS16 | ENSP00000392726 | ENSP00000230582 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family. | 0.613 |
POM121L2 | ZNF184 | ENSP00000392726 | ENSP00000211936 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | Zinc finger protein 184; May be involved in transcriptional regulation. | 0.571 |
PRSS16 | POM121L2 | ENSP00000230582 | ENSP00000392726 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family. | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | 0.613 |
PRSS16 | ZNF184 | ENSP00000230582 | ENSP00000211936 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family. | Zinc finger protein 184; May be involved in transcriptional regulation. | 0.436 |
RRP8 | ZNF184 | ENSP00000254605 | ENSP00000211936 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | Zinc finger protein 184; May be involved in transcriptional regulation. | 0.453 |
TRIM28 | ZNF184 | ENSP00000253024 | ENSP00000211936 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 184; May be involved in transcriptional regulation. | 0.635 |
ZNF184 | HMGN4 | ENSP00000211936 | ENSP00000366798 | Zinc finger protein 184; May be involved in transcriptional regulation. | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family. | 0.416 |
ZNF184 | ITPKB | ENSP00000211936 | ENSP00000411152 | Zinc finger protein 184; May be involved in transcriptional regulation. | Inositol-trisphosphate 3-kinase B. | 0.430 |
ZNF184 | PDIK1L | ENSP00000211936 | ENSP00000363389 | Zinc finger protein 184; May be involved in transcriptional regulation. | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like. | 0.538 |
ZNF184 | POM121L2 | ENSP00000211936 | ENSP00000392726 | Zinc finger protein 184; May be involved in transcriptional regulation. | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | 0.571 |
ZNF184 | PRSS16 | ENSP00000211936 | ENSP00000230582 | Zinc finger protein 184; May be involved in transcriptional regulation. | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family. | 0.436 |
ZNF184 | RRP8 | ENSP00000211936 | ENSP00000254605 | Zinc finger protein 184; May be involved in transcriptional regulation. | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | 0.453 |
ZNF184 | TRIM28 | ENSP00000211936 | ENSP00000253024 | Zinc finger protein 184; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.635 |