node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMH2 | ZMYND12 | ENSP00000454913 | ENSP00000361646 | Armadillo-like helical domain-containing protein 2; Armadillo like helical domain containing 2. | Zinc finger MYND-type containing 12. | 0.654 |
ARMH2 | ZNF34 | ENSP00000454913 | ENSP00000341528 | Armadillo-like helical domain-containing protein 2; Armadillo like helical domain containing 2. | Zinc finger protein 34; May be involved in transcriptional regulation. | 0.570 |
COMMD5 | ZNF34 | ENSP00000394331 | ENSP00000341528 | COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B. | Zinc finger protein 34; May be involved in transcriptional regulation. | 0.414 |
CYHR1 | MROH1 | ENSP00000433769 | ENSP00000435565 | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | Maestro heat like repeat family member 1. | 0.794 |
CYHR1 | ZNF16 | ENSP00000433769 | ENSP00000276816 | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.404 |
CYHR1 | ZNF34 | ENSP00000433769 | ENSP00000341528 | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | Zinc finger protein 34; May be involved in transcriptional regulation. | 0.534 |
MROH1 | CYHR1 | ENSP00000435565 | ENSP00000433769 | Maestro heat like repeat family member 1. | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | 0.794 |
MROH1 | ZNF34 | ENSP00000435565 | ENSP00000341528 | Maestro heat like repeat family member 1. | Zinc finger protein 34; May be involved in transcriptional regulation. | 0.498 |
MYC | TRIM28 | ENSP00000478887 | ENSP00000253024 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.722 |
MYC | ZNF34 | ENSP00000478887 | ENSP00000341528 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | Zinc finger protein 34; May be involved in transcriptional regulation. | 0.449 |
NKPD1 | ZNF34 | ENSP00000321976 | ENSP00000341528 | NTPase KAP family P-loop domain containing 1. | Zinc finger protein 34; May be involved in transcriptional regulation. | 0.606 |
TRIM28 | MYC | ENSP00000253024 | ENSP00000478887 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.722 |
TRIM28 | ZNF34 | ENSP00000253024 | ENSP00000341528 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 34; May be involved in transcriptional regulation. | 0.697 |
ZMYND12 | ARMH2 | ENSP00000361646 | ENSP00000454913 | Zinc finger MYND-type containing 12. | Armadillo-like helical domain-containing protein 2; Armadillo like helical domain containing 2. | 0.654 |
ZMYND12 | ZNF34 | ENSP00000361646 | ENSP00000341528 | Zinc finger MYND-type containing 12. | Zinc finger protein 34; May be involved in transcriptional regulation. | 0.458 |
ZNF16 | CYHR1 | ENSP00000276816 | ENSP00000433769 | Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis. Belongs to the krueppel C2H2-type zinc-finger protein family. | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | 0.404 |
ZNF16 | ZNF34 | ENSP00000276816 | ENSP00000341528 | Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis. Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 34; May be involved in transcriptional regulation. | 0.597 |
ZNF34 | ARMH2 | ENSP00000341528 | ENSP00000454913 | Zinc finger protein 34; May be involved in transcriptional regulation. | Armadillo-like helical domain-containing protein 2; Armadillo like helical domain containing 2. | 0.570 |
ZNF34 | COMMD5 | ENSP00000341528 | ENSP00000394331 | Zinc finger protein 34; May be involved in transcriptional regulation. | COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B. | 0.414 |
ZNF34 | CYHR1 | ENSP00000341528 | ENSP00000433769 | Zinc finger protein 34; May be involved in transcriptional regulation. | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | 0.534 |