node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTL9 | ZNF442 | ENSP00000316674 | ENSP00000242804 | Actin-like protein 9; Actin like 9. | Zinc finger protein 442; May be involved in transcriptional regulation. | 0.401 |
PM20D1 | ZNF442 | ENSP00000356104 | ENSP00000242804 | N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration. | Zinc finger protein 442; May be involved in transcriptional regulation. | 0.400 |
PTPRH | ZNF442 | ENSP00000365528 | ENSP00000242804 | Receptor-type tyrosine-protein phosphatase H; Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activat [...] | Zinc finger protein 442; May be involved in transcriptional regulation. | 0.433 |
RNF39 | ZNF442 | ENSP00000244360 | ENSP00000242804 | RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance. | Zinc finger protein 442; May be involved in transcriptional regulation. | 0.440 |
SLC25A44 | ZNF442 | ENSP00000407560 | ENSP00000242804 | Solute carrier family 25 member 44; Mitochondrial solute transporter which transports branched- chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT) (By similarity). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis. | Zinc finger protein 442; May be involved in transcriptional regulation. | 0.480 |
STK38 | ZNF442 | ENSP00000229812 | ENSP00000242804 | Serine/threonine-protein kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. | Zinc finger protein 442; May be involved in transcriptional regulation. | 0.410 |
TRIM28 | ZNF442 | ENSP00000253024 | ENSP00000242804 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 442; May be involved in transcriptional regulation. | 0.522 |
ZNF442 | ACTL9 | ENSP00000242804 | ENSP00000316674 | Zinc finger protein 442; May be involved in transcriptional regulation. | Actin-like protein 9; Actin like 9. | 0.401 |
ZNF442 | PM20D1 | ENSP00000242804 | ENSP00000356104 | Zinc finger protein 442; May be involved in transcriptional regulation. | N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration. | 0.400 |
ZNF442 | PTPRH | ENSP00000242804 | ENSP00000365528 | Zinc finger protein 442; May be involved in transcriptional regulation. | Receptor-type tyrosine-protein phosphatase H; Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activat [...] | 0.433 |
ZNF442 | RNF39 | ENSP00000242804 | ENSP00000244360 | Zinc finger protein 442; May be involved in transcriptional regulation. | RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance. | 0.440 |
ZNF442 | SLC25A44 | ENSP00000242804 | ENSP00000407560 | Zinc finger protein 442; May be involved in transcriptional regulation. | Solute carrier family 25 member 44; Mitochondrial solute transporter which transports branched- chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT) (By similarity). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis. | 0.480 |
ZNF442 | STK38 | ENSP00000242804 | ENSP00000229812 | Zinc finger protein 442; May be involved in transcriptional regulation. | Serine/threonine-protein kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. | 0.410 |
ZNF442 | TRIM28 | ENSP00000242804 | ENSP00000253024 | Zinc finger protein 442; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.522 |