STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF483Zinc finger protein 483; May be involved in transcriptional regulation. (744 aa)    
Predicted Functional Partners:
ZNF446
Zinc finger protein 446; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
 
  
0.798
ZKSCAN4
Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family.
    
  
0.777
ZNF462
Zinc finger protein 462; Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation.
   
  
 0.692
SCAND1
SCAN domain-containing protein 1; May regulate transcriptional activity.
    
  
0.684
ZKSCAN3
Zinc finger protein with KRAB and SCAN domains 3; Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
  
  
0.684
ZNF24
Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro; Belongs to the krueppel C2H2-type zinc-finger protein family.
    
  
0.663
ZNF397
Zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor.
  
  
0.652
ZNF496
Zinc finger protein 496; DNA-binding transcription factor that can both act as an activator and a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family.
    
 
0.646
ZNF232
Zinc finger protein 232; May be involved in transcriptional regulation.
    
  
0.631
ZNF197
Zinc finger protein 197; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
    
  
0.628
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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