node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BLOC1S3 | DGCR6L | ENSP00000393840 | ENSP00000248879 | Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. | Protein DGCR6L; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches; Belongs to the gonadal family. | 0.429 |
BLOC1S3 | ZNF490 | ENSP00000393840 | ENSP00000311521 | Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.463 |
CYP20A1 | ZNF490 | ENSP00000348380 | ENSP00000311521 | Cytochrome P450 family 20 subfamily A member 1. | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.471 |
DGCR6L | BLOC1S3 | ENSP00000248879 | ENSP00000393840 | Protein DGCR6L; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches; Belongs to the gonadal family. | Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. | 0.429 |
DGCR6L | ZNF490 | ENSP00000248879 | ENSP00000311521 | Protein DGCR6L; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches; Belongs to the gonadal family. | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.489 |
LRIG2 | ZNF490 | ENSP00000355396 | ENSP00000311521 | Leucine rich repeats and immunoglobulin like domains 2. | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.541 |
NBPF3 | ZNF490 | ENSP00000316782 | ENSP00000311521 | Neuroblastoma breakpoint family member 3; NBPF member 3; Belongs to the NBPF family. | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.589 |
PRADC1 | ZNF490 | ENSP00000258083 | ENSP00000311521 | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.571 |
SYNE1 | ZNF490 | ENSP00000356224 | ENSP00000311521 | Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus- centrosome attachment and nuclear migrati [...] | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.464 |
TRIM28 | ZNF490 | ENSP00000253024 | ENSP00000311521 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.567 |
TTC22 | ZNF490 | ENSP00000360323 | ENSP00000311521 | Tetratricopeptide repeat domain 22. | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.475 |
ZNF283 | ZNF490 | ENSP00000484852 | ENSP00000311521 | Zinc finger protein 283; May be involved in transcriptional regulation. | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.460 |
ZNF490 | BLOC1S3 | ENSP00000311521 | ENSP00000393840 | Zinc finger protein 490; May be involved in transcriptional regulation. | Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. | 0.463 |
ZNF490 | CYP20A1 | ENSP00000311521 | ENSP00000348380 | Zinc finger protein 490; May be involved in transcriptional regulation. | Cytochrome P450 family 20 subfamily A member 1. | 0.471 |
ZNF490 | DGCR6L | ENSP00000311521 | ENSP00000248879 | Zinc finger protein 490; May be involved in transcriptional regulation. | Protein DGCR6L; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches; Belongs to the gonadal family. | 0.489 |
ZNF490 | LRIG2 | ENSP00000311521 | ENSP00000355396 | Zinc finger protein 490; May be involved in transcriptional regulation. | Leucine rich repeats and immunoglobulin like domains 2. | 0.541 |
ZNF490 | NBPF3 | ENSP00000311521 | ENSP00000316782 | Zinc finger protein 490; May be involved in transcriptional regulation. | Neuroblastoma breakpoint family member 3; NBPF member 3; Belongs to the NBPF family. | 0.589 |
ZNF490 | PRADC1 | ENSP00000311521 | ENSP00000258083 | Zinc finger protein 490; May be involved in transcriptional regulation. | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | 0.571 |
ZNF490 | SYNE1 | ENSP00000311521 | ENSP00000356224 | Zinc finger protein 490; May be involved in transcriptional regulation. | Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus- centrosome attachment and nuclear migrati [...] | 0.464 |
ZNF490 | TRIM28 | ENSP00000311521 | ENSP00000253024 | Zinc finger protein 490; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.567 |