STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF526Zinc finger protein 526; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (670 aa)    
Predicted Functional Partners:
ZSCAN22
Zinc finger and SCAN domain-containing protein 22; May be involved in transcriptional regulation.
   
   
0.630
C21orf58
Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.
   
  
 0.553
ZC3H14
Zinc finger CCCH domain-containing protein 14; Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
   
 
 0.502
CNFN
Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family.
   
 
 0.476
ARL14EP
ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.
   
  
 0.448
DDX51
ATP-dependent RNA helicase DDX51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits; Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
   
 
 0.438
PRR19
Proline-rich protein 19; Proline rich 19.
   
  
 0.427
MEGF8
Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.
   
  
 0.419
ZNF500
Zinc finger protein 500; May be involved in transcriptional regulation.
   
   
0.412
DEDD2
DNA-binding death effector domain-containing protein 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
   
  
 0.410
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.