node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2orf42 | ZNF557 | ENSP00000264434 | ENSP00000252840 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.467 |
LRRC8E | RABEPK | ENSP00000479953 | ENSP00000362639 | Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depen [...] | Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport. | 0.446 |
LRRC8E | TTC8 | ENSP00000479953 | ENSP00000482306 | Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depen [...] | Tetratricopeptide repeat protein 8; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl [...] | 0.423 |
LRRC8E | ZNF557 | ENSP00000479953 | ENSP00000252840 | Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depen [...] | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.503 |
MBD3L4 | OR4F17 | ENSP00000370801 | ENSP00000467301 | methyl-CpG binding domain protein 3 like 4. | Olfactory receptor 4F17; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.610 |
MBD3L4 | ZNF557 | ENSP00000370801 | ENSP00000252840 | methyl-CpG binding domain protein 3 like 4. | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.538 |
OR4F17 | MBD3L4 | ENSP00000467301 | ENSP00000370801 | Olfactory receptor 4F17; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | methyl-CpG binding domain protein 3 like 4. | 0.610 |
OR4F17 | ZNF557 | ENSP00000467301 | ENSP00000252840 | Olfactory receptor 4F17; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.471 |
PGBD4 | ZNF557 | ENSP00000380872 | ENSP00000252840 | piggyBac transposable element derived 4. | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.490 |
RABEPK | LRRC8E | ENSP00000362639 | ENSP00000479953 | Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport. | Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depen [...] | 0.446 |
RABEPK | TTC8 | ENSP00000362639 | ENSP00000482306 | Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport. | Tetratricopeptide repeat protein 8; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl [...] | 0.463 |
RABEPK | ZNF557 | ENSP00000362639 | ENSP00000252840 | Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport. | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.544 |
THAP6 | ZNF557 | ENSP00000309007 | ENSP00000252840 | THAP domain containing 6. | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.535 |
TRIM28 | ZNF268 | ENSP00000253024 | ENSP00000444412 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.747 |
TRIM28 | ZNF557 | ENSP00000253024 | ENSP00000252840 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.643 |
TTC8 | LRRC8E | ENSP00000482306 | ENSP00000479953 | Tetratricopeptide repeat protein 8; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl [...] | Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depen [...] | 0.423 |
TTC8 | RABEPK | ENSP00000482306 | ENSP00000362639 | Tetratricopeptide repeat protein 8; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl [...] | Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport. | 0.463 |
TTC8 | ZNF557 | ENSP00000482306 | ENSP00000252840 | Tetratricopeptide repeat protein 8; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl [...] | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.490 |
ZNF268 | TRIM28 | ENSP00000444412 | ENSP00000253024 | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.747 |
ZNF268 | ZNF557 | ENSP00000444412 | ENSP00000252840 | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.488 |