node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEACAM7 | ZNF574 | ENSP00000006724 | ENSP00000222339 | CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family. | Zinc finger protein 574; May be involved in transcriptional regulation. | 0.550 |
CNFN | PAFAH1B3 | ENSP00000222032 | ENSP00000444935 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain; Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. | 0.479 |
CNFN | TMEM145 | ENSP00000222032 | ENSP00000301204 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Transmembrane protein 145. | 0.486 |
CNFN | ZNF574 | ENSP00000222032 | ENSP00000222339 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Zinc finger protein 574; May be involved in transcriptional regulation. | 0.596 |
E4F1 | WDR24 | ENSP00000301727 | ENSP00000293883 | Transcription factor E4F1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. | GATOR complex protein WDR24; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Belongs to the WD repeat WDR24 family. | 0.787 |
E4F1 | ZNF408 | ENSP00000301727 | ENSP00000309606 | Transcription factor E4F1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. | Zinc finger protein 408; May be involved in transcriptional regulation. | 0.545 |
E4F1 | ZNF574 | ENSP00000301727 | ENSP00000222339 | Transcription factor E4F1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. | Zinc finger protein 574; May be involved in transcriptional regulation. | 0.668 |
PAFAH1B3 | CNFN | ENSP00000444935 | ENSP00000222032 | Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain; Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | 0.479 |
PAFAH1B3 | TMEM145 | ENSP00000444935 | ENSP00000301204 | Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain; Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. | Transmembrane protein 145. | 0.588 |
PAFAH1B3 | ZNF574 | ENSP00000444935 | ENSP00000222339 | Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain; Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. | Zinc finger protein 574; May be involved in transcriptional regulation. | 0.529 |
PLEKHJ1 | ZNF574 | ENSP00000464955 | ENSP00000222339 | Pleckstrin homology domain containing J1. | Zinc finger protein 574; May be involved in transcriptional regulation. | 0.516 |
RPSA | ZNF574 | ENSP00000389351 | ENSP00000222339 | 40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Dengue virus [...] | Zinc finger protein 574; May be involved in transcriptional regulation. | 0.617 |
THAP12 | ZNF574 | ENSP00000260045 | ENSP00000222339 | 52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. | Zinc finger protein 574; May be involved in transcriptional regulation. | 0.592 |
TMEM145 | CNFN | ENSP00000301204 | ENSP00000222032 | Transmembrane protein 145. | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | 0.486 |
TMEM145 | PAFAH1B3 | ENSP00000301204 | ENSP00000444935 | Transmembrane protein 145. | Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain; Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. | 0.588 |
TMEM145 | ZNF574 | ENSP00000301204 | ENSP00000222339 | Transmembrane protein 145. | Zinc finger protein 574; May be involved in transcriptional regulation. | 0.588 |
WDR24 | E4F1 | ENSP00000293883 | ENSP00000301727 | GATOR complex protein WDR24; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Belongs to the WD repeat WDR24 family. | Transcription factor E4F1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. | 0.787 |
WDR24 | ZNF408 | ENSP00000293883 | ENSP00000309606 | GATOR complex protein WDR24; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Belongs to the WD repeat WDR24 family. | Zinc finger protein 408; May be involved in transcriptional regulation. | 0.538 |
WDR24 | ZNF574 | ENSP00000293883 | ENSP00000222339 | GATOR complex protein WDR24; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Belongs to the WD repeat WDR24 family. | Zinc finger protein 574; May be involved in transcriptional regulation. | 0.533 |
ZNF408 | E4F1 | ENSP00000309606 | ENSP00000301727 | Zinc finger protein 408; May be involved in transcriptional regulation. | Transcription factor E4F1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. | 0.545 |