node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FIZ1 | ISOC2 | ENSP00000221665 | ENSP00000085068 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). | Isochorismatase domain containing 2. | 0.538 |
FIZ1 | NAT14 | ENSP00000221665 | ENSP00000205194 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). | N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro. | 0.619 |
FIZ1 | PPP6R1 | ENSP00000221665 | ENSP00000414202 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. | 0.486 |
FIZ1 | ZNF579 | ENSP00000221665 | ENSP00000320188 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). | Zinc finger protein 579; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.439 |
ISOC2 | FIZ1 | ENSP00000085068 | ENSP00000221665 | Isochorismatase domain containing 2. | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). | 0.538 |
ISOC2 | NAT14 | ENSP00000085068 | ENSP00000205194 | Isochorismatase domain containing 2. | N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro. | 0.525 |
ISOC2 | PPP6R1 | ENSP00000085068 | ENSP00000414202 | Isochorismatase domain containing 2. | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. | 0.473 |
ISOC2 | RDH13 | ENSP00000085068 | ENSP00000391121 | Isochorismatase domain containing 2. | Retinol dehydrogenase 13; Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency. Has no activity toward steroids. | 0.501 |
ISOC2 | ZNF579 | ENSP00000085068 | ENSP00000320188 | Isochorismatase domain containing 2. | Zinc finger protein 579; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.592 |
LBR | ZNF579 | ENSP00000339883 | ENSP00000320188 | Delta(14)-sterol reductase LBR; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane. | Zinc finger protein 579; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.629 |
NAT14 | FIZ1 | ENSP00000205194 | ENSP00000221665 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro. | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). | 0.619 |
NAT14 | ISOC2 | ENSP00000205194 | ENSP00000085068 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro. | Isochorismatase domain containing 2. | 0.525 |
NAT14 | PPP6R1 | ENSP00000205194 | ENSP00000414202 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro. | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. | 0.469 |
NAT14 | ZNF579 | ENSP00000205194 | ENSP00000320188 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro. | Zinc finger protein 579; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.725 |
PPP6R1 | FIZ1 | ENSP00000414202 | ENSP00000221665 | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). | 0.486 |
PPP6R1 | ISOC2 | ENSP00000414202 | ENSP00000085068 | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. | Isochorismatase domain containing 2. | 0.473 |
PPP6R1 | NAT14 | ENSP00000414202 | ENSP00000205194 | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. | N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro. | 0.469 |
PPP6R1 | ZNF579 | ENSP00000414202 | ENSP00000320188 | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. | Zinc finger protein 579; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.521 |
RBM23 | ZNF579 | ENSP00000352956 | ENSP00000320188 | Probable RNA-binding protein 23; Probable RNA-binding protein. May be involved in pre-mRNA splicing process; Belongs to the splicing factor SR family. | Zinc finger protein 579; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.695 |
RDH13 | ISOC2 | ENSP00000391121 | ENSP00000085068 | Retinol dehydrogenase 13; Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency. Has no activity toward steroids. | Isochorismatase domain containing 2. | 0.501 |