node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6orf141 | ZNF586 | ENSP00000434602 | ENSP00000379458 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141. | Zinc finger protein 586; May be involved in transcriptional regulation. | 0.446 |
EFCAB7 | ZNF586 | ENSP00000360129 | ENSP00000379458 | EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. | Zinc finger protein 586; May be involved in transcriptional regulation. | 0.414 |
IFNA1 | IFNA17 | ENSP00000276927 | ENSP00000411940 | Interferon alpha-1/13; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. | 0.797 |
IFNA1 | ZNF586 | ENSP00000276927 | ENSP00000379458 | Interferon alpha-1/13; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. | Zinc finger protein 586; May be involved in transcriptional regulation. | 0.601 |
IFNA17 | IFNA1 | ENSP00000411940 | ENSP00000276927 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. | Interferon alpha-1/13; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. | 0.797 |
IFNA17 | ZNF586 | ENSP00000411940 | ENSP00000379458 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. | Zinc finger protein 586; May be involved in transcriptional regulation. | 0.781 |
TRIM28 | ZNF211 | ENSP00000253024 | ENSP00000299871 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 211; May be involved in transcriptional regulation. | 0.614 |
TRIM28 | ZNF586 | ENSP00000253024 | ENSP00000379458 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 586; May be involved in transcriptional regulation. | 0.519 |
ZNF211 | TRIM28 | ENSP00000299871 | ENSP00000253024 | Zinc finger protein 211; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.614 |
ZNF211 | ZNF586 | ENSP00000299871 | ENSP00000379458 | Zinc finger protein 211; May be involved in transcriptional regulation. | Zinc finger protein 586; May be involved in transcriptional regulation. | 0.410 |
ZNF586 | C6orf141 | ENSP00000379458 | ENSP00000434602 | Zinc finger protein 586; May be involved in transcriptional regulation. | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141. | 0.446 |
ZNF586 | EFCAB7 | ENSP00000379458 | ENSP00000360129 | Zinc finger protein 586; May be involved in transcriptional regulation. | EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. | 0.414 |
ZNF586 | IFNA1 | ENSP00000379458 | ENSP00000276927 | Zinc finger protein 586; May be involved in transcriptional regulation. | Interferon alpha-1/13; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. | 0.601 |
ZNF586 | IFNA17 | ENSP00000379458 | ENSP00000411940 | Zinc finger protein 586; May be involved in transcriptional regulation. | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. | 0.781 |
ZNF586 | TRIM28 | ENSP00000379458 | ENSP00000253024 | Zinc finger protein 586; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.519 |
ZNF586 | ZNF211 | ENSP00000379458 | ENSP00000299871 | Zinc finger protein 586; May be involved in transcriptional regulation. | Zinc finger protein 211; May be involved in transcriptional regulation. | 0.410 |