node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATN1 | RERE | ENSP00000379915 | ENSP00000338629 | Atrophin-1; Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. | 0.679 |
ATN1 | ZNF608 | ENSP00000379915 | ENSP00000307746 | Atrophin-1; Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription. | 0.782 |
DNAJC27 | FPGT-TNNI3K | ENSP00000264711 | ENSP00000450895 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | FPGT-TNNI3K readthrough. | 0.627 |
DNAJC27 | GPRC5B | ENSP00000264711 | ENSP00000300571 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | G-protein coupled receptor family C group 5 member B; Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. | 0.516 |
DNAJC27 | MTIF3 | ENSP00000264711 | ENSP00000370508 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. | 0.573 |
DNAJC27 | NUDT3 | ENSP00000264711 | ENSP00000476119 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Diphosphoinositol polyphosphate phosphohydrolase 1; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able t [...] | 0.588 |
DNAJC27 | POC5 | ENSP00000264711 | ENSP00000410216 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation; Belongs to the POC5 family. | 0.614 |
DNAJC27 | QPCTL | ENSP00000264711 | ENSP00000012049 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Glutaminyl-peptide cyclotransferase-like protein; Responsible for the biosynthesis of pyroglutamyl peptides. | 0.597 |
DNAJC27 | TMEM160 | ENSP00000264711 | ENSP00000253047 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Transmembrane protein 160. | 0.621 |
DNAJC27 | ZNF608 | ENSP00000264711 | ENSP00000307746 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription. | 0.606 |
FPGT-TNNI3K | DNAJC27 | ENSP00000450895 | ENSP00000264711 | FPGT-TNNI3K readthrough. | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | 0.627 |
FPGT-TNNI3K | GPRC5B | ENSP00000450895 | ENSP00000300571 | FPGT-TNNI3K readthrough. | G-protein coupled receptor family C group 5 member B; Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. | 0.586 |
FPGT-TNNI3K | MTIF3 | ENSP00000450895 | ENSP00000370508 | FPGT-TNNI3K readthrough. | Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. | 0.596 |
FPGT-TNNI3K | NUDT3 | ENSP00000450895 | ENSP00000476119 | FPGT-TNNI3K readthrough. | Diphosphoinositol polyphosphate phosphohydrolase 1; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able t [...] | 0.585 |
FPGT-TNNI3K | POC5 | ENSP00000450895 | ENSP00000410216 | FPGT-TNNI3K readthrough. | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation; Belongs to the POC5 family. | 0.596 |
FPGT-TNNI3K | QPCTL | ENSP00000450895 | ENSP00000012049 | FPGT-TNNI3K readthrough. | Glutaminyl-peptide cyclotransferase-like protein; Responsible for the biosynthesis of pyroglutamyl peptides. | 0.620 |
FPGT-TNNI3K | TMEM160 | ENSP00000450895 | ENSP00000253047 | FPGT-TNNI3K readthrough. | Transmembrane protein 160. | 0.599 |
FPGT-TNNI3K | ZNF608 | ENSP00000450895 | ENSP00000307746 | FPGT-TNNI3K readthrough. | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription. | 0.570 |
GPRC5B | DNAJC27 | ENSP00000300571 | ENSP00000264711 | G-protein coupled receptor family C group 5 member B; Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | 0.516 |
GPRC5B | FPGT-TNNI3K | ENSP00000300571 | ENSP00000450895 | G-protein coupled receptor family C group 5 member B; Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. | FPGT-TNNI3K readthrough. | 0.586 |