node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRA2 | ZNF697 | ENSP00000296785 | ENSP00000396857 | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity). | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.450 |
GAPVD1 | ZNF697 | ENSP00000377665 | ENSP00000396857 | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.507 |
PPP5D1 | ZNF697 | ENSP00000392262 | ENSP00000396857 | Protein PPP5D1; PPP5 tetratricopeptide repeat domain containing 1. | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.548 |
TRIM28 | ZNF697 | ENSP00000253024 | ENSP00000396857 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.522 |
TRIM28 | ZNF761 | ENSP00000253024 | ENSP00000481271 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 761. | 0.652 |
ZBTB21 | ZNF697 | ENSP00000308759 | ENSP00000396857 | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor. | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.432 |
ZBTB21 | ZZZ3 | ENSP00000308759 | ENSP00000359837 | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor. | ZZ-type zinc finger-containing protein 3; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. | 0.411 |
ZFYVE16 | ZNF697 | ENSP00000426848 | ENSP00000396857 | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.480 |
ZNF608 | ZNF697 | ENSP00000307746 | ENSP00000396857 | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription. | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.407 |
ZNF608 | ZZZ3 | ENSP00000307746 | ENSP00000359837 | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription. | ZZ-type zinc finger-containing protein 3; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. | 0.496 |
ZNF697 | ANKRA2 | ENSP00000396857 | ENSP00000296785 | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity). | 0.450 |
ZNF697 | GAPVD1 | ENSP00000396857 | ENSP00000377665 | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | 0.507 |
ZNF697 | PPP5D1 | ENSP00000396857 | ENSP00000392262 | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Protein PPP5D1; PPP5 tetratricopeptide repeat domain containing 1. | 0.548 |
ZNF697 | TRIM28 | ENSP00000396857 | ENSP00000253024 | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.522 |
ZNF697 | ZBTB21 | ENSP00000396857 | ENSP00000308759 | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor. | 0.432 |
ZNF697 | ZFYVE16 | ENSP00000396857 | ENSP00000426848 | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. | 0.480 |
ZNF697 | ZNF608 | ENSP00000396857 | ENSP00000307746 | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription. | 0.407 |
ZNF697 | ZNF761 | ENSP00000396857 | ENSP00000481271 | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 761. | 0.448 |
ZNF697 | ZZZ3 | ENSP00000396857 | ENSP00000359837 | Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | ZZ-type zinc finger-containing protein 3; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. | 0.419 |
ZNF761 | TRIM28 | ENSP00000481271 | ENSP00000253024 | Zinc finger protein 761. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.652 |