node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TRIM28 | ZNF28 | ENSP00000253024 | ENSP00000397693 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 28; May be involved in transcriptional regulation. | 0.627 |
TRIM28 | ZNF350 | ENSP00000253024 | ENSP00000243644 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3. | 0.987 |
TRIM28 | ZNF468 | ENSP00000253024 | ENSP00000470381 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 468; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.668 |
TRIM28 | ZNF564 | ENSP00000253024 | ENSP00000340004 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 564; May be involved in transcriptional regulation. | 0.580 |
TRIM28 | ZNF701 | ENSP00000253024 | ENSP00000444339 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 701; May be involved in transcriptional regulation. | 0.615 |
TRIM61 | ZNF701 | ENSP00000332288 | ENSP00000444339 | Putative tripartite motif-containing protein 61; Tripartite motif containing 61. | Zinc finger protein 701; May be involved in transcriptional regulation. | 0.464 |
ZER1 | ZNF701 | ENSP00000291900 | ENSP00000444339 | Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation. | Zinc finger protein 701; May be involved in transcriptional regulation. | 0.651 |
ZNF28 | TRIM28 | ENSP00000397693 | ENSP00000253024 | Zinc finger protein 28; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.627 |
ZNF28 | ZNF468 | ENSP00000397693 | ENSP00000470381 | Zinc finger protein 28; May be involved in transcriptional regulation. | Zinc finger protein 468; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.785 |
ZNF28 | ZNF525 | ENSP00000397693 | ENSP00000417696 | Zinc finger protein 28; May be involved in transcriptional regulation. | Zinc finger protein 525. | 0.464 |
ZNF28 | ZNF701 | ENSP00000397693 | ENSP00000444339 | Zinc finger protein 28; May be involved in transcriptional regulation. | Zinc finger protein 701; May be involved in transcriptional regulation. | 0.517 |
ZNF28 | ZNF816 | ENSP00000397693 | ENSP00000350295 | Zinc finger protein 28; May be involved in transcriptional regulation. | Zinc finger protein 816; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.554 |
ZNF350 | TRIM28 | ENSP00000243644 | ENSP00000253024 | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.987 |
ZNF350 | ZNF701 | ENSP00000243644 | ENSP00000444339 | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3. | Zinc finger protein 701; May be involved in transcriptional regulation. | 0.479 |
ZNF468 | TRIM28 | ENSP00000470381 | ENSP00000253024 | Zinc finger protein 468; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.668 |
ZNF468 | ZNF28 | ENSP00000470381 | ENSP00000397693 | Zinc finger protein 468; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 28; May be involved in transcriptional regulation. | 0.785 |
ZNF468 | ZNF701 | ENSP00000470381 | ENSP00000444339 | Zinc finger protein 468; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 701; May be involved in transcriptional regulation. | 0.542 |
ZNF468 | ZNF816 | ENSP00000470381 | ENSP00000350295 | Zinc finger protein 468; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 816; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.769 |
ZNF525 | ZNF28 | ENSP00000417696 | ENSP00000397693 | Zinc finger protein 525. | Zinc finger protein 28; May be involved in transcriptional regulation. | 0.464 |
ZNF525 | ZNF701 | ENSP00000417696 | ENSP00000444339 | Zinc finger protein 525. | Zinc finger protein 701; May be involved in transcriptional regulation. | 0.486 |