searching ... STRING: functional protein association networks

ACAT2 - Acetyl-CoA acetyltransferase, cytosolic; Involved in the biosynthetic pathway of cholesterol. [a.k.a. Q9BWD1, R-HSA-556833, ENST00000472052.1]

MMP1 - 22 kDa interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. [a.k.a. R-HSA-202733, 4AUO, CLG]

H2BC4 - Histone H2B type 1-C/E/F/G/I; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [a.k.a. CH471087, 8347, NP_003517.2]

TRAT1 - T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. [a.k.a. R-HSA-9006925, TRIM, R-HSA-162582]

MMP3 - Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. [a.k.a. 1UMT, R-HSA-388396, AK223283]

PCYT1B - Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis. [a.k.a. ENST00000379140, NM_001163264.2, ENSP00000265783]

SEC23B - Protein transport protein Sec23B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. [a.k.a. NM_032986, LRG_1134t1, ENST00000650089.1]

LARP1 - La-related protein 1; RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif lead [...] [a.k.a. ENST00000285894, MGC19556, LARP1_HUMAN]

DESI1 - Desumoylating isopeptidase 1; Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm ; Belongs to the DeSI family. [a.k.a. AF038183, HPA053415, NX_Q6ICB0]

CDC14A - Dual specificity protein phosphatase CDC14A; Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing. [a.k.a. ENST00000336454, 3.1.3.16, HPA023783]

SPRR4 - Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family. [a.k.a. Q96PI1, XP_016855971.1, NM_173080.3]

ETV1 - ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'; Belongs to the ETS family. [a.k.a. ENSG00000006468, NM_001163148.1, ENST00000405192]

IL36A - Interleukin-36 alpha; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL- 36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and ce [...] [a.k.a. IL-1 epsilon, R-HSA-446652, XP_016859295]

SMPDL3B - Acid sphingomyelinase-like phosphodiesterase 3b; Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity). Belongs to the acid sphingomyelinase family. [a.k.a. sphingomyelin phosphodiesterase acid like 3B, NM_014474, Q5T0Z0]

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