searching ... STRING: functional protein association networks

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The following proteins in Homo sapiens appear to match your input.
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101 query items

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1) '9606.ENSP00000336914':

FGD3 - FYVE, RhoGEF and PH domain-containing protein 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). [a.k.a. FGD3-207, R-HSA-388396, ENST00000416701.6]

2) '9606.ENSP00000316746':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

3) '9606.ENSP00000325708':

CD37 - Leukocyte antigen CD37; CD37 molecule. [a.k.a. ENST00000597033, TSPAN26, NP_001035120.1]

4) '9606.ENSP00000271324':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

5) '9606.ENSP00000370503':

CCM2 - Cerebral cavernous malformations 2 protein; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). [a.k.a. ENST00000543541, OSM, XP_006715848]

6) '9606.ENSP00000365261':

LST1 - Leukocyte-specific transcript 1 protein; Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. [a.k.a. ENSP00000365260, HGNC:14189, ENST00000396112.6]

7) '9606.ENSP00000353238':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

8) '9606.ENSP00000256935':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

9) '9606.ENSP00000256958':

SLCO1B1 - Solute carrier organic anion transporter family member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. Belongs to the organo anion transporter (TC 2.A.60) family. [a.k.a. OATP-C, LST-1, R-HSA-556833]

10) '9606.ENSP00000352575':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

11) '9606.ENSP00000348635':

JAML - Junctional adhesion molecule-like; Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferat [...] [a.k.a. CCDS8391, R-HSA-202733, JAML-209]

12) '9606.ENSP00000265440':

TFEC - Transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By sim [...] [a.k.a. CCDS5762, O14948, XP_011514271.1]

13) '9606.ENSP00000370889':

DENND1C - DENN domain-containing protein 1C; Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. [a.k.a. ENSP00000466583, BAG64313.1, XM_024451727]

14) '9606.ENSP00000268389':

IGSF6 - Immunoglobulin superfamily member 6. [a.k.a. NP_005840, ENSG00000140749, Q8WWD8]

15) '9606.ENSP00000342681':

CD5 - T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. [a.k.a. ENSG00000110448, NM_001346456.1, NP_055022]

16) '9606.ENSP00000262709':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

17) '9606.ENSP00000364180':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

18) '9606.ENSP00000380227':

ITGA4 - Integrin alpha-4; Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions wit [...] [a.k.a. CHEMBL278, R-HSA-202733, CD49d]

19) '9606.ENSP00000365318':

NFKBIL1 - NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. [a.k.a. AQY76956.1, ENST00000376145.8, F2Z390]

20) '9606.ENSP00000278888':

MS4A2 - High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor- bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy; Belongs to the MS4A family. [a.k.a. NX_Q01362, ENSP00000482594, R-HSA-2871796]

101 query items

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