searching ... STRING: functional protein association networks

ADAM33 - Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain 33. [a.k.a. XR_937152.1, C20orf153, NP_001269376.1]

MYZAP - Myocardial zonula adherens protein; Plays a role in cellular signaling via Rho-related GTP- binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). Belongs to the MYZAP family. [a.k.a. P0CAP1, HGNC:43444, Q8NC58]

PALLD - Palladin; Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have [...] [a.k.a. NP_001354498.1, ENSP00000422135, XP_011530073]

PLIN5 - Perilipin-5; Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hyd [...] [a.k.a. Perilipin 5, NP_001013728, ENST00000590350]

LIMA1 - LIM domain and actin-binding protein 1; Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, [...] [a.k.a. uc001rwg.5, AF157325, BAA90914.1]

PARVB - Beta-parvin; Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. Belongs to the parvin family. [a.k.a. ENSP00000347833, 29780, ENST00000619710.4]

NEXN - Nexilin; Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. [a.k.a. ENSP00000343928, UPI000059CFF7, AK057954]

MLYCD - Malonyl-CoA decarboxylase, mitochondrial; Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in mus [...] [a.k.a. Malonyl-CoA decarboxylase, UPI0000128FD5, ENST00000566309.2]

KCNK5 - Potassium channel subfamily K member 5; pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations. [a.k.a. ENSG00000164626, TASK-2, TASK2]

FGD5 - FYVE, RhoGEF and PH domain-containing protein 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF- induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. [a.k.a. XM_011533422.1, NM_001320276, uc003bzc.4]

MYLPF - Myosin light chain, phosphorylatable, fast skeletal muscle. [a.k.a. myosin, light chain 11, regulatory, MYLPF-201, Fast skeletal myosin light chain 2]

DUPD1 - Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. [a.k.a. XP_011538049.1, 3.1.3.16, CCDS31223.1]

GLI3 - Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] [a.k.a. UPI000020EE4C, R-HSA-162582, GLI3-207]

GAS1 - Growth arrest-specific protein 1; Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. [a.k.a. P54826, CCDS6674, AAI36587.1]

CCDC85A - Coiled-coil domain-containing protein 85A; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. [a.k.a. NM_001348513, Coiled-coil domain-containing protein 85A, NM_001348512]

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