searching ... STRING: functional protein association networks

The following proteins in Homo sapiens appear to match your input.
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101 query items

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1) '9606.ENSP00000360215':

ZBP1 - Z-DNA-binding protein 1; Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). [a.k.a. NM_001323966.2, NP_001310895.1, DLM1]

2) '9606.ENSP00000358092':

PRDM1 - PR domain zinc finger protein 1; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue- resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, [...] [a.k.a. ENST00000369096, ENST00000613999, PRDM1-201]

3) '9606.ENSP00000334594':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

4) '9606.ENSP00000352834':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

5) '9606.ENSP00000404833':

TAPBP - Tapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). [a.k.a. NGS-17, XM_017011227, ENSP00000404833]

6) '9606.ENSP00000237500':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

7) '9606.ENSP00000374558':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

8) '9606.ENSP00000308351':

MLKL - Mixed lineage kinase domain-like protein; Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function. [a.k.a. ENST00000306247.11, ENST00000308807.11, 197259]

9) '9606.ENSP00000349325':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

10) '9606.ENSP00000332116':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

11) '9606.ENSP00000264951':

XRN1 - 5'-3' exoribonuclease 1; Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). [a.k.a. XP_016862131, HPA035005, ENSP00000264951]

12) '9606.ENSP00000384192':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

13) '9606.ENSP00000464833':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

14) '9606.ENSP00000294517':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

15) '9606.ENSP00000203629':

LAG3 - Secreted lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/P [...] [a.k.a. A8K7T9, ENSG00000089692, BAF84793.1]

16) '9606.ENSP00000231509':

NR3C1 - Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand- dependent manner which recruits the RNA helicase UPF1 and the mRNA- decapping enzyme D [...] [a.k.a. NM_001364183, 5CBX, NP_001351111.1]

17) '9606.ENSP00000256722':

CMPK2 - UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. [a.k.a. UPI0000208DE7, NP_997198, ENST00000458098]

18) '9606.ENSP00000332816':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

19) '9606.ENSP00000260184':

DDX60L - Probable ATP-dependent RNA helicase DDX60-like; DExD/H-box 60 like; Belongs to the helicase family. [a.k.a. XR_938792, Probable ATP-dependent RNA helicase DDX60-like, XP_016864319]

20) '9606.ENSP00000230568':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

101 query items

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