searching ... STRING: functional protein association networks

TNNT1 - Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. [a.k.a. ENST00000593194.5, HPA058448, ENST00000587758.5]

DLGAP5 - Disks large-associated protein 5; Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. [a.k.a. Disks large-associated protein 5, NM_001146015.1, R-HSA-162582]

PRDM1 - PR domain zinc finger protein 1; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue- resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, [...] [a.k.a. ENST00000369096, ENST00000613999, PRDM1-201]

STAC3 - SH3 and cysteine-rich domain-containing protein 3; Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membran [...] [a.k.a. ENST00000554578, STAC3-201, NX_Q96MF2]

CLEC12A - C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. [a.k.a. NP_001287659.1, hsa:160364, XM_006719035.3]

RCSD1 - CapZ-interacting protein; Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. [a.k.a. AL031733, MK2S4, RCSD1-204]

SERPINB10 - Serpin B10; Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus. [a.k.a. AAH96217.1, UPI0000E5A171, U35459]

ADCY9 - Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors. [a.k.a. I3L342, AC9, R-HSA-388396]

PLB1 - Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). [a.k.a. R-HSA-388396, R-HSA-196854, XP_011530895.1]

ENO3 - Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. [a.k.a. ENO3-201, NP_001180432.1, B4DUI6]

MYLPF - Myosin light chain, phosphorylatable, fast skeletal muscle. [a.k.a. myosin, light chain 11, regulatory, MYLPF-201, Fast skeletal myosin light chain 2]

MYOM3 - Myomesin-3; May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. [a.k.a. MYOM3-204, hsa:127294, Q5VTT5]

CLEC7A - C-type lectin domain family 7 member A; Lectin that functions as pattern receptor specific for beta- 1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). Necessary for the TLR2- mediated inflammatory response and for TLR2-mediated activation of NF- kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does [...] [a.k.a. ENSG00000172243, CD369, XM_017019823]

FBXW11 - F-box/WD repeat-containing protein 11; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediat [...] [a.k.a. XM_005265855.5, R-HSA-8951664, Fbw11]

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